Cargando…

Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment

Approximately 30% of pancreatic cancer patients harbor targetable mutations. However, there has been no therapy targeting these molecules clinically. Nucleic acid medicines show high specificity and can target RNAs. Nucleic acid medicine is expected to be the next-generation treatment next to small...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamakawa, Keiko, Nakano-Narusawa, Yuko, Hashimoto, Nozomi, Yokohira, Masanao, Matsuda, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747711/
https://www.ncbi.nlm.nih.gov/pubmed/31470511
http://dx.doi.org/10.3390/ijms20174224
_version_ 1783451956733280256
author Yamakawa, Keiko
Nakano-Narusawa, Yuko
Hashimoto, Nozomi
Yokohira, Masanao
Matsuda, Yoko
author_facet Yamakawa, Keiko
Nakano-Narusawa, Yuko
Hashimoto, Nozomi
Yokohira, Masanao
Matsuda, Yoko
author_sort Yamakawa, Keiko
collection PubMed
description Approximately 30% of pancreatic cancer patients harbor targetable mutations. However, there has been no therapy targeting these molecules clinically. Nucleic acid medicines show high specificity and can target RNAs. Nucleic acid medicine is expected to be the next-generation treatment next to small molecules and antibodies. There are several kinds of nucleic acid drugs, including antisense oligonucleotides, small interfering RNAs, microRNAs, aptamers, decoys, and CpG oligodeoxynucleotides. In this review, we provide an update on current research of nucleic acid-based therapies. Despite the challenging obstacles, we hope that nucleic acid drugs will have a significant impact on the treatment of pancreatic cancer. The combination of genetic diagnosis using next generation sequencing and targeted therapy may provide effective precision medicine for pancreatic cancer patients.
format Online
Article
Text
id pubmed-6747711
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67477112019-09-27 Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment Yamakawa, Keiko Nakano-Narusawa, Yuko Hashimoto, Nozomi Yokohira, Masanao Matsuda, Yoko Int J Mol Sci Review Approximately 30% of pancreatic cancer patients harbor targetable mutations. However, there has been no therapy targeting these molecules clinically. Nucleic acid medicines show high specificity and can target RNAs. Nucleic acid medicine is expected to be the next-generation treatment next to small molecules and antibodies. There are several kinds of nucleic acid drugs, including antisense oligonucleotides, small interfering RNAs, microRNAs, aptamers, decoys, and CpG oligodeoxynucleotides. In this review, we provide an update on current research of nucleic acid-based therapies. Despite the challenging obstacles, we hope that nucleic acid drugs will have a significant impact on the treatment of pancreatic cancer. The combination of genetic diagnosis using next generation sequencing and targeted therapy may provide effective precision medicine for pancreatic cancer patients. MDPI 2019-08-29 /pmc/articles/PMC6747711/ /pubmed/31470511 http://dx.doi.org/10.3390/ijms20174224 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yamakawa, Keiko
Nakano-Narusawa, Yuko
Hashimoto, Nozomi
Yokohira, Masanao
Matsuda, Yoko
Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
title Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
title_full Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
title_fullStr Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
title_full_unstemmed Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
title_short Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
title_sort development and clinical trials of nucleic acid medicines for pancreatic cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747711/
https://www.ncbi.nlm.nih.gov/pubmed/31470511
http://dx.doi.org/10.3390/ijms20174224
work_keys_str_mv AT yamakawakeiko developmentandclinicaltrialsofnucleicacidmedicinesforpancreaticcancertreatment
AT nakanonarusawayuko developmentandclinicaltrialsofnucleicacidmedicinesforpancreaticcancertreatment
AT hashimotonozomi developmentandclinicaltrialsofnucleicacidmedicinesforpancreaticcancertreatment
AT yokohiramasanao developmentandclinicaltrialsofnucleicacidmedicinesforpancreaticcancertreatment
AT matsudayoko developmentandclinicaltrialsofnucleicacidmedicinesforpancreaticcancertreatment