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Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
Approximately 30% of pancreatic cancer patients harbor targetable mutations. However, there has been no therapy targeting these molecules clinically. Nucleic acid medicines show high specificity and can target RNAs. Nucleic acid medicine is expected to be the next-generation treatment next to small...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747711/ https://www.ncbi.nlm.nih.gov/pubmed/31470511 http://dx.doi.org/10.3390/ijms20174224 |
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author | Yamakawa, Keiko Nakano-Narusawa, Yuko Hashimoto, Nozomi Yokohira, Masanao Matsuda, Yoko |
author_facet | Yamakawa, Keiko Nakano-Narusawa, Yuko Hashimoto, Nozomi Yokohira, Masanao Matsuda, Yoko |
author_sort | Yamakawa, Keiko |
collection | PubMed |
description | Approximately 30% of pancreatic cancer patients harbor targetable mutations. However, there has been no therapy targeting these molecules clinically. Nucleic acid medicines show high specificity and can target RNAs. Nucleic acid medicine is expected to be the next-generation treatment next to small molecules and antibodies. There are several kinds of nucleic acid drugs, including antisense oligonucleotides, small interfering RNAs, microRNAs, aptamers, decoys, and CpG oligodeoxynucleotides. In this review, we provide an update on current research of nucleic acid-based therapies. Despite the challenging obstacles, we hope that nucleic acid drugs will have a significant impact on the treatment of pancreatic cancer. The combination of genetic diagnosis using next generation sequencing and targeted therapy may provide effective precision medicine for pancreatic cancer patients. |
format | Online Article Text |
id | pubmed-6747711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67477112019-09-27 Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment Yamakawa, Keiko Nakano-Narusawa, Yuko Hashimoto, Nozomi Yokohira, Masanao Matsuda, Yoko Int J Mol Sci Review Approximately 30% of pancreatic cancer patients harbor targetable mutations. However, there has been no therapy targeting these molecules clinically. Nucleic acid medicines show high specificity and can target RNAs. Nucleic acid medicine is expected to be the next-generation treatment next to small molecules and antibodies. There are several kinds of nucleic acid drugs, including antisense oligonucleotides, small interfering RNAs, microRNAs, aptamers, decoys, and CpG oligodeoxynucleotides. In this review, we provide an update on current research of nucleic acid-based therapies. Despite the challenging obstacles, we hope that nucleic acid drugs will have a significant impact on the treatment of pancreatic cancer. The combination of genetic diagnosis using next generation sequencing and targeted therapy may provide effective precision medicine for pancreatic cancer patients. MDPI 2019-08-29 /pmc/articles/PMC6747711/ /pubmed/31470511 http://dx.doi.org/10.3390/ijms20174224 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yamakawa, Keiko Nakano-Narusawa, Yuko Hashimoto, Nozomi Yokohira, Masanao Matsuda, Yoko Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment |
title | Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment |
title_full | Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment |
title_fullStr | Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment |
title_full_unstemmed | Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment |
title_short | Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment |
title_sort | development and clinical trials of nucleic acid medicines for pancreatic cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747711/ https://www.ncbi.nlm.nih.gov/pubmed/31470511 http://dx.doi.org/10.3390/ijms20174224 |
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