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Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma

PURPOSE: To evaluate and analyze the efficacy and prognostic factors of intensity-modulated radiotherapy in 250 patients with cervical and upper esophageal carcinoma. PATIENTS AND METHODS: From September 2009 to September 2016, we retrospectively analyzed 250 patients with cervical and upper esophag...

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Autores principales: Zhang, Jiaqi, Zhang, Wencheng, Zhang, Baozhong, Qian, Dong, Li, Xiaoxia, Zhang, Hualei, Wang, Qi, Zhao, Lujun, Pang, Qingsong, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748035/
https://www.ncbi.nlm.nih.gov/pubmed/31571986
http://dx.doi.org/10.2147/CMAR.S203575
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author Zhang, Jiaqi
Zhang, Wencheng
Zhang, Baozhong
Qian, Dong
Li, Xiaoxia
Zhang, Hualei
Wang, Qi
Zhao, Lujun
Pang, Qingsong
Wang, Ping
author_facet Zhang, Jiaqi
Zhang, Wencheng
Zhang, Baozhong
Qian, Dong
Li, Xiaoxia
Zhang, Hualei
Wang, Qi
Zhao, Lujun
Pang, Qingsong
Wang, Ping
author_sort Zhang, Jiaqi
collection PubMed
description PURPOSE: To evaluate and analyze the efficacy and prognostic factors of intensity-modulated radiotherapy in 250 patients with cervical and upper esophageal carcinoma. PATIENTS AND METHODS: From September 2009 to September 2016, we retrospectively analyzed 250 patients with cervical and upper esophageal carcinoma treated with intensity-modulated radiotherapy (IMRT). In our study, all patients received IMRT, 54 patients with cervical esophageal carcinoma and 196 patients with upper esophageal carcinoma. Treatment response, survival status and failure modes of treatment were observed, and prognostic factors were analyzed. RESULTS: The median survival time was 22.60 months and 3-year survival rate was 42%. The median progress-free survival time was 14.52 months and 3-year progress-free survival rate was 29.3%. The median survival time and the median progress-free survival time for cervical esophageal carcinoma were 20.40 and 15.15 months, respectively. The median survival time and the median progress-free survival time for upper esophageal carcinoma were 25.80 and 14.52 months, respectively (P>0.05). The significant clinical factors associated with survival were patient age, radiotherapy dose and T stages (P<0.05). Radiotherapy dose and concurrent chemoradiotherapy were the significant clinical factors related to progression-free survival (P<0.05). Recurrence appeared in 55.2% patients, including local recurrence in 22.40%, region relapse in 10.40% and distant metastasis in 12.40%. Local recurrence was the main mode of treatment failure. During treatment, the main treatment-related acute toxicity was leukocytopenia and anemia. CONCLUSION: In this study, IMRT demonstrated clinical benefit and well-tolerated toxicity in patients with cervical and upper esophageal carcinoma.
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spelling pubmed-67480352019-09-30 Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma Zhang, Jiaqi Zhang, Wencheng Zhang, Baozhong Qian, Dong Li, Xiaoxia Zhang, Hualei Wang, Qi Zhao, Lujun Pang, Qingsong Wang, Ping Cancer Manag Res Original Research PURPOSE: To evaluate and analyze the efficacy and prognostic factors of intensity-modulated radiotherapy in 250 patients with cervical and upper esophageal carcinoma. PATIENTS AND METHODS: From September 2009 to September 2016, we retrospectively analyzed 250 patients with cervical and upper esophageal carcinoma treated with intensity-modulated radiotherapy (IMRT). In our study, all patients received IMRT, 54 patients with cervical esophageal carcinoma and 196 patients with upper esophageal carcinoma. Treatment response, survival status and failure modes of treatment were observed, and prognostic factors were analyzed. RESULTS: The median survival time was 22.60 months and 3-year survival rate was 42%. The median progress-free survival time was 14.52 months and 3-year progress-free survival rate was 29.3%. The median survival time and the median progress-free survival time for cervical esophageal carcinoma were 20.40 and 15.15 months, respectively. The median survival time and the median progress-free survival time for upper esophageal carcinoma were 25.80 and 14.52 months, respectively (P>0.05). The significant clinical factors associated with survival were patient age, radiotherapy dose and T stages (P<0.05). Radiotherapy dose and concurrent chemoradiotherapy were the significant clinical factors related to progression-free survival (P<0.05). Recurrence appeared in 55.2% patients, including local recurrence in 22.40%, region relapse in 10.40% and distant metastasis in 12.40%. Local recurrence was the main mode of treatment failure. During treatment, the main treatment-related acute toxicity was leukocytopenia and anemia. CONCLUSION: In this study, IMRT demonstrated clinical benefit and well-tolerated toxicity in patients with cervical and upper esophageal carcinoma. Dove 2019-09-10 /pmc/articles/PMC6748035/ /pubmed/31571986 http://dx.doi.org/10.2147/CMAR.S203575 Text en © 2019 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhang, Jiaqi
Zhang, Wencheng
Zhang, Baozhong
Qian, Dong
Li, Xiaoxia
Zhang, Hualei
Wang, Qi
Zhao, Lujun
Pang, Qingsong
Wang, Ping
Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
title Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
title_full Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
title_fullStr Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
title_full_unstemmed Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
title_short Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
title_sort clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748035/
https://www.ncbi.nlm.nih.gov/pubmed/31571986
http://dx.doi.org/10.2147/CMAR.S203575
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