The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cells (CSCs) through the activation of a PN gene signature. Besides prototypical ASCL1 PN t...

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Detalles Bibliográficos
Autores principales: Narayanan, Ashwin, Gagliardi, Filippo, Gallotti, Alberto L., Mazzoleni, Stefania, Cominelli, Manuela, Fagnocchi, Luca, Pala, Mauro, Piras, Ignazio S., Zordan, Paola, Moretta, Nicole, Tratta, Elisa, Brugnara, Gianluca, Altabella, Luisa, Bozzuto, Giuseppina, Gorombei, Petra, Molinari, Agnese, Padua, Rose-Ann, Bulfone, Alessandro, Politi, Letterio S., Falini, Andrea, Castellano, Antonella, Mortini, Pietro, Zippo, Alessio, Poliani, Pietro L., Galli, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748080/
https://www.ncbi.nlm.nih.gov/pubmed/30538287
http://dx.doi.org/10.1038/s41418-018-0248-7

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