SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

SPOP is one of the important subunits for CUL3/SPOP/RBX1 complex tightly connected with tumorigenesis. However, its exact roles in different cancers remain debatable. Here, we identify CYCLIN E1, as a novel substrate for SPOP. SPOP directly interacts with CYCLIN E1 and specific regulates its stabili...

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Detalles Bibliográficos
Autores principales: Ju, Lin-Gao, Zhu, Yuan, Long, Qiao-Yun, Li, Xue-Jing, Lin, Xiang, Tang, Shan-Bo, Yin, Lei, Xiao, Yu, Wang, Xing-Huan, Li, Lianyun, Zhang, Lei, Wu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748103/
https://www.ncbi.nlm.nih.gov/pubmed/30237511
http://dx.doi.org/10.1038/s41418-018-0198-0

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