The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression

Progression of non-alcoholic fatty liver disease (NAFLD) from steatosis to non-alcoholic steatohepatitis (NASH) is a key step of NASH pathogenesis. The AP-1 transcription factor c-Jun is an important regulator of hepatic stress responses, but its contribution to NASH pathogenesis remains poorly defi...

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Detalles Bibliográficos
Autores principales: Schulien, Isabel, Hockenjos, Birgit, Schmitt-Graeff, Annette, Perdekamp, Markus Große, Follo, Marie, Thimme, Robert, Hasselblatt, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748141/
https://www.ncbi.nlm.nih.gov/pubmed/30778201
http://dx.doi.org/10.1038/s41418-018-0239-8

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