Function, clinical application, and strategies of Pre-mRNA splicing in cancer

Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional...

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Autores principales: Di, Cuixia, Syafrizayanti, Zhang, Qianjing, Chen, Yuhong, Wang, Yupei, Zhang, Xuetian, Liu, Yang, Sun, Chao, Zhang, Hong, Hoheisel, Jörg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748147/
https://www.ncbi.nlm.nih.gov/pubmed/30464224
http://dx.doi.org/10.1038/s41418-018-0231-3
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author Di, Cuixia
Syafrizayanti
Zhang, Qianjing
Chen, Yuhong
Wang, Yupei
Zhang, Xuetian
Liu, Yang
Sun, Chao
Zhang, Hong
Hoheisel, Jörg D.
author_facet Di, Cuixia
Syafrizayanti
Zhang, Qianjing
Chen, Yuhong
Wang, Yupei
Zhang, Xuetian
Liu, Yang
Sun, Chao
Zhang, Hong
Hoheisel, Jörg D.
author_sort Di, Cuixia
collection PubMed
description Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional aspects in cancer: proliferation, metastasis and apoptosis. Importantly, clinical function of aberrant splicing isoforms is also discussed, in particular concerning drug resistance and radiosensitivity. Furthermore, this review discusses emerging strategies how to modulate pathologic aberrant splicing isoforms, which are attractive, novel therapeutic agents in cancer. Last we outline current and future directions of isoforms diagnostic methodologies reported so far in cancer. Thus, it is highlighting significance of aberrant splicing isoforms as markers for cancer and as targets for cancer therapy.
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spelling pubmed-67481472019-09-18 Function, clinical application, and strategies of Pre-mRNA splicing in cancer Di, Cuixia Syafrizayanti Zhang, Qianjing Chen, Yuhong Wang, Yupei Zhang, Xuetian Liu, Yang Sun, Chao Zhang, Hong Hoheisel, Jörg D. Cell Death Differ Review Article Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional aspects in cancer: proliferation, metastasis and apoptosis. Importantly, clinical function of aberrant splicing isoforms is also discussed, in particular concerning drug resistance and radiosensitivity. Furthermore, this review discusses emerging strategies how to modulate pathologic aberrant splicing isoforms, which are attractive, novel therapeutic agents in cancer. Last we outline current and future directions of isoforms diagnostic methodologies reported so far in cancer. Thus, it is highlighting significance of aberrant splicing isoforms as markers for cancer and as targets for cancer therapy. Nature Publishing Group UK 2018-11-21 2019-07 /pmc/articles/PMC6748147/ /pubmed/30464224 http://dx.doi.org/10.1038/s41418-018-0231-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Di, Cuixia
Syafrizayanti
Zhang, Qianjing
Chen, Yuhong
Wang, Yupei
Zhang, Xuetian
Liu, Yang
Sun, Chao
Zhang, Hong
Hoheisel, Jörg D.
Function, clinical application, and strategies of Pre-mRNA splicing in cancer
title Function, clinical application, and strategies of Pre-mRNA splicing in cancer
title_full Function, clinical application, and strategies of Pre-mRNA splicing in cancer
title_fullStr Function, clinical application, and strategies of Pre-mRNA splicing in cancer
title_full_unstemmed Function, clinical application, and strategies of Pre-mRNA splicing in cancer
title_short Function, clinical application, and strategies of Pre-mRNA splicing in cancer
title_sort function, clinical application, and strategies of pre-mrna splicing in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748147/
https://www.ncbi.nlm.nih.gov/pubmed/30464224
http://dx.doi.org/10.1038/s41418-018-0231-3
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