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The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a...

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Detalles Bibliográficos
Autores principales: Sullivan, Lucy C, Shaw, Evangeline M, Stankovic, Sanda, Snell, Gregory I, Brooks, Andrew G, Westall, Glen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748302/
https://www.ncbi.nlm.nih.gov/pubmed/31548887
http://dx.doi.org/10.1002/cti2.1078
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author Sullivan, Lucy C
Shaw, Evangeline M
Stankovic, Sanda
Snell, Gregory I
Brooks, Andrew G
Westall, Glen P
author_facet Sullivan, Lucy C
Shaw, Evangeline M
Stankovic, Sanda
Snell, Gregory I
Brooks, Andrew G
Westall, Glen P
author_sort Sullivan, Lucy C
collection PubMed
description Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post‐transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation.
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spelling pubmed-67483022019-09-23 The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing Sullivan, Lucy C Shaw, Evangeline M Stankovic, Sanda Snell, Gregory I Brooks, Andrew G Westall, Glen P Clin Transl Immunology Special Feature Reviews Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post‐transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation. John Wiley and Sons Inc. 2019-09-17 /pmc/articles/PMC6748302/ /pubmed/31548887 http://dx.doi.org/10.1002/cti2.1078 Text en © 2019 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Feature Reviews
Sullivan, Lucy C
Shaw, Evangeline M
Stankovic, Sanda
Snell, Gregory I
Brooks, Andrew G
Westall, Glen P
The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
title The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
title_full The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
title_fullStr The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
title_full_unstemmed The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
title_short The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
title_sort complex existence of γδ t cells following transplantation: the good, the bad and the simply confusing
topic Special Feature Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748302/
https://www.ncbi.nlm.nih.gov/pubmed/31548887
http://dx.doi.org/10.1002/cti2.1078
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