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The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing
Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748302/ https://www.ncbi.nlm.nih.gov/pubmed/31548887 http://dx.doi.org/10.1002/cti2.1078 |
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author | Sullivan, Lucy C Shaw, Evangeline M Stankovic, Sanda Snell, Gregory I Brooks, Andrew G Westall, Glen P |
author_facet | Sullivan, Lucy C Shaw, Evangeline M Stankovic, Sanda Snell, Gregory I Brooks, Andrew G Westall, Glen P |
author_sort | Sullivan, Lucy C |
collection | PubMed |
description | Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post‐transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation. |
format | Online Article Text |
id | pubmed-6748302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67483022019-09-23 The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing Sullivan, Lucy C Shaw, Evangeline M Stankovic, Sanda Snell, Gregory I Brooks, Andrew G Westall, Glen P Clin Transl Immunology Special Feature Reviews Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post‐transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation. John Wiley and Sons Inc. 2019-09-17 /pmc/articles/PMC6748302/ /pubmed/31548887 http://dx.doi.org/10.1002/cti2.1078 Text en © 2019 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Feature Reviews Sullivan, Lucy C Shaw, Evangeline M Stankovic, Sanda Snell, Gregory I Brooks, Andrew G Westall, Glen P The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing |
title | The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing |
title_full | The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing |
title_fullStr | The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing |
title_full_unstemmed | The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing |
title_short | The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing |
title_sort | complex existence of γδ t cells following transplantation: the good, the bad and the simply confusing |
topic | Special Feature Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748302/ https://www.ncbi.nlm.nih.gov/pubmed/31548887 http://dx.doi.org/10.1002/cti2.1078 |
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