Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents

Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors. Here, we present crystal structures of amyloid-forming segments from the major curli subunit, CsgA, revealing steric...

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Detalles Bibliográficos
Autores principales: Perov, Sergei, Lidor, Ofir, Salinas, Nir, Golan, Nimrod, Tayeb- Fligelman, Einav, Deshmukh, Maya, Willbold, Dieter, Landau, Meytal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748439/
https://www.ncbi.nlm.nih.gov/pubmed/31469892
http://dx.doi.org/10.1371/journal.ppat.1007978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748439/
https://www.ncbi.nlm.nih.gov/pubmed/31469892
http://dx.doi.org/10.1371/journal.ppat.1007978

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