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Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents
Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors. Here, we present crystal structures of amyloid-forming segments from the major curli subunit, CsgA, revealing steric...
Autores principales: | Perov, Sergei, Lidor, Ofir, Salinas, Nir, Golan, Nimrod, Tayeb- Fligelman, Einav, Deshmukh, Maya, Willbold, Dieter, Landau, Meytal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748439/ https://www.ncbi.nlm.nih.gov/pubmed/31469892 http://dx.doi.org/10.1371/journal.ppat.1007978 |
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