Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis

HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is undergoing rapid scale-up in the United States. While FTC/TDF is typically well tolerated, to our knowledge, cranial nerve pathology associated with FTC/TDF has no...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Slyke, Loraine, Scott, Mia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748473/
https://www.ncbi.nlm.nih.gov/pubmed/29534653
http://dx.doi.org/10.1177/2325958218760846
_version_ 1783452097978564608
author Van Slyke, Loraine
Scott, Mia
author_facet Van Slyke, Loraine
Scott, Mia
author_sort Van Slyke, Loraine
collection PubMed
description HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is undergoing rapid scale-up in the United States. While FTC/TDF is typically well tolerated, to our knowledge, cranial nerve pathology associated with FTC/TDF has not been previously described. We report the case of a 35-year-old patient who began FTC/TDF PrEP and developed acute trigeminal neuralgia. The neurologic symptoms resolved after treatment discontinuation and recurred upon rechallenge, resulting in permanent discontinuation of PrEP treatment.
format Online
Article
Text
id pubmed-6748473
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-67484732019-11-04 Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis Van Slyke, Loraine Scott, Mia J Int Assoc Provid AIDS Care Case Report HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is undergoing rapid scale-up in the United States. While FTC/TDF is typically well tolerated, to our knowledge, cranial nerve pathology associated with FTC/TDF has not been previously described. We report the case of a 35-year-old patient who began FTC/TDF PrEP and developed acute trigeminal neuralgia. The neurologic symptoms resolved after treatment discontinuation and recurred upon rechallenge, resulting in permanent discontinuation of PrEP treatment. SAGE Publications 2018-03-14 /pmc/articles/PMC6748473/ /pubmed/29534653 http://dx.doi.org/10.1177/2325958218760846 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Van Slyke, Loraine
Scott, Mia
Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis
title Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis
title_full Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis
title_fullStr Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis
title_full_unstemmed Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis
title_short Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis
title_sort acute trigeminal neuralgia associated with initiation of emtricitabine/tenofovir for hiv pre-exposure prophylaxis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748473/
https://www.ncbi.nlm.nih.gov/pubmed/29534653
http://dx.doi.org/10.1177/2325958218760846
work_keys_str_mv AT vanslykeloraine acutetrigeminalneuralgiaassociatedwithinitiationofemtricitabinetenofovirforhivpreexposureprophylaxis
AT scottmia acutetrigeminalneuralgiaassociatedwithinitiationofemtricitabinetenofovirforhivpreexposureprophylaxis

Ejemplares similares