Comparative Assessment of the Magnitude of Hyperlipidemia in HIV-Infected Patients Receiving Lopinavir/r- and Atazanavir/r-Based Antiretroviral Drugs

OBJECTIVE: To assess prevalence of hyperlipidemia in patients receiving lopinavir boosted with ritonavir (LPV/r) and atazanavir boosted with ritonavir (ATV/r) antiretroviral drugs. METHODS: HIV-infected patients (300) were recruited in the study between December 2015 and April 2016. Lipid profile including triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) were assessed. RESULTS: Prevalence of derangement in TG was 71.0% in patients using LPV/r compared to 44% in those using ATV/r (P = .01). Use of LPV/r was independently associated with increased total cholesterol (TC; P = .001) and TG (P = .0003). Females had raised levels of TC compared to males (P = .00008). Body mass index of ≥ 25 kg/m(2) was also associated with raised TC (P = .002) and LDL-C (P = .006). CONCLUSION: LPV/r was significantly associated with lipid derangements, indicating the need to regularly monitor lipid profile in patients using LPV/r.