Hematological and biochemical parameters for Chinese rhesus macaque

Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters ha...

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Detalles Bibliográficos
Autores principales: Yu, Wenhai, Hao, Xianhui, Yang, Fengmei, Ma, Jin, Zhao, Yuan, Li, Yanyan, Wang, Junbin, Xu, Hongjie, Chen, Lixiong, Liu, Quan, Duan, Suqin, Yang, Yaping, Huang, Fen, He, Zhanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748566/
https://www.ncbi.nlm.nih.gov/pubmed/31527891
http://dx.doi.org/10.1371/journal.pone.0222338
Descripción
Sumario:Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.

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