Hematological and biochemical parameters for Chinese rhesus macaque

Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters ha...

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Autores principales: Yu, Wenhai, Hao, Xianhui, Yang, Fengmei, Ma, Jin, Zhao, Yuan, Li, Yanyan, Wang, Junbin, Xu, Hongjie, Chen, Lixiong, Liu, Quan, Duan, Suqin, Yang, Yaping, Huang, Fen, He, Zhanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748566/
https://www.ncbi.nlm.nih.gov/pubmed/31527891
http://dx.doi.org/10.1371/journal.pone.0222338
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author Yu, Wenhai
Hao, Xianhui
Yang, Fengmei
Ma, Jin
Zhao, Yuan
Li, Yanyan
Wang, Junbin
Xu, Hongjie
Chen, Lixiong
Liu, Quan
Duan, Suqin
Yang, Yaping
Huang, Fen
He, Zhanlong
author_facet Yu, Wenhai
Hao, Xianhui
Yang, Fengmei
Ma, Jin
Zhao, Yuan
Li, Yanyan
Wang, Junbin
Xu, Hongjie
Chen, Lixiong
Liu, Quan
Duan, Suqin
Yang, Yaping
Huang, Fen
He, Zhanlong
author_sort Yu, Wenhai
collection PubMed
description Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.
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spelling pubmed-67485662019-09-27 Hematological and biochemical parameters for Chinese rhesus macaque Yu, Wenhai Hao, Xianhui Yang, Fengmei Ma, Jin Zhao, Yuan Li, Yanyan Wang, Junbin Xu, Hongjie Chen, Lixiong Liu, Quan Duan, Suqin Yang, Yaping Huang, Fen He, Zhanlong PLoS One Research Article Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models. Public Library of Science 2019-09-17 /pmc/articles/PMC6748566/ /pubmed/31527891 http://dx.doi.org/10.1371/journal.pone.0222338 Text en © 2019 Yu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yu, Wenhai
Hao, Xianhui
Yang, Fengmei
Ma, Jin
Zhao, Yuan
Li, Yanyan
Wang, Junbin
Xu, Hongjie
Chen, Lixiong
Liu, Quan
Duan, Suqin
Yang, Yaping
Huang, Fen
He, Zhanlong
Hematological and biochemical parameters for Chinese rhesus macaque
title Hematological and biochemical parameters for Chinese rhesus macaque
title_full Hematological and biochemical parameters for Chinese rhesus macaque
title_fullStr Hematological and biochemical parameters for Chinese rhesus macaque
title_full_unstemmed Hematological and biochemical parameters for Chinese rhesus macaque
title_short Hematological and biochemical parameters for Chinese rhesus macaque
title_sort hematological and biochemical parameters for chinese rhesus macaque
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748566/
https://www.ncbi.nlm.nih.gov/pubmed/31527891
http://dx.doi.org/10.1371/journal.pone.0222338
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