Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis

Site-specific antibody-drug conjugates (ADCs) are designed to overcome the heterogeneity observed with first-generation ADCs that use random conjugation to surface-exposed lysine residues or conjugation to interchain disulfide bonds. Despite significantly enhanced homogeneity, however, the productio...

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Detalles Bibliográficos
Autores principales: Cao, Mingyan, De Mel, Niluka, Jiao, Yang, Howard, James, Parthemore, Conner, Korman, Samuel, Thompson, Christopher, Wendeler, Michaela, Liu, Dengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748582/
https://www.ncbi.nlm.nih.gov/pubmed/31198090
http://dx.doi.org/10.1080/19420862.2019.1624127

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