Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

Biotherapeutics may contain a multitude of different post-translational modifications (PTMs) that need to be assessed and possibly monitored and controlled to ensure reproducible product quality. During early development of biotherapeutics, unexpected PTMs might be prevented by in silico identificat...

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Detalles Bibliográficos
Autores principales: Tyshchuk, Oksana, Gstöttner, Christoph, Funk, Dennis, Nicolardi, Simone, Frost, Stefan, Klostermann, Stefan, Becker, Tim, Jolkver, Elena, Schumacher, Felix, Koller, Claudia Ferrara, Völger, Hans Rainer, Wuhrer, Manfred, Bulau, Patrick, Mølhøj, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748591/
https://www.ncbi.nlm.nih.gov/pubmed/31339437
http://dx.doi.org/10.1080/19420862.2019.1635865

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