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Measuring the effects of macromolecular crowding on antibody function with biolayer interferometry
Biotherapeutic proteins are commonly dosed at high concentrations into the blood, which is an inherently complex, crowded solution with substantial protein content. The effects of macromolecular crowding may lead to an appreciable level of non-specific hetero-association in this physiological enviro...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748605/ https://www.ncbi.nlm.nih.gov/pubmed/31401928 http://dx.doi.org/10.1080/19420862.2019.1647744 |