Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells

Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by combining ‘knob-into-hole’ mutations for heavy chain...

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Detalles Bibliográficos
Autores principales: Joshi, Kamal Kishore, Phung, Wilson, Han, Guanghui, Yin, Yiyuan, Kim, Ingrid, Sandoval, Wendy, Carter, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748609/
https://www.ncbi.nlm.nih.gov/pubmed/31286843
http://dx.doi.org/10.1080/19420862.2019.1640549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748609/
https://www.ncbi.nlm.nih.gov/pubmed/31286843
http://dx.doi.org/10.1080/19420862.2019.1640549

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