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Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells
Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by combining ‘knob-into-hole’ mutations for heavy chain...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748609/ https://www.ncbi.nlm.nih.gov/pubmed/31286843 http://dx.doi.org/10.1080/19420862.2019.1640549 |