Using bispecific antibodies in forced degradation studies to analyze the structure–function relationships of symmetrically and asymmetrically modified antibodies

Forced degradation experiments of monoclonal antibodies (mAbs) aid in the identification of critical quality attributes (CQAs) by studying the impact of post-translational modifications (PTMs), such as oxidation, deamidation, glycation, and isomerization, on biological functions. Structure-function...

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Detalles Bibliográficos
Autores principales: Evans, Adam R., Capaldi, Michael T., Goparaju, Geetha, Colter, David, Shi, Frank F., Aubert, Sarah, Li, Lian-Chao, Mo, Jingjie, Lewis, Michael J., Hu, Ping, Alfonso, Pedro, Mehndiratta, Promod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748611/
https://www.ncbi.nlm.nih.gov/pubmed/31161859
http://dx.doi.org/10.1080/19420862.2019.1618675

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