Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

Agonism of members of the tumor necrosis factor receptor superfamily (TNFRSF) with monoclonal antibodies is of high therapeutic interest due to their role in immune regulation and cell proliferation. A major hurdle for pharmacologic activation of this receptor class is the requirement for high-order...

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Detalles Bibliográficos
Autores principales: Yang, Yanli, Yeh, Sherry H., Madireddi, Shravan, Matochko, Wadim L., Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F., Leonard, Brandon, Scales, Suzie J., Zhu, Jing W., Christensen, Erin, Hang, Julie Q., Brezski, Randall J., Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M., Lazar, Greg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748612/
https://www.ncbi.nlm.nih.gov/pubmed/31156033
http://dx.doi.org/10.1080/19420862.2019.1625662

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