Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα

Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and adaptive immune responses. Unlike CD47, which is expressed ubiquitously, SIRPα expression is mainly restricted to myeloid cells and neur...

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Detalles Bibliográficos
Autores principales: Sim, Janet, Sockolosky, Jonathan T., Sangalang, Emma, Izquierdo, Shelley, Pedersen, Darlene, Harriman, William, Wibowo, Ardian S., Carter, Josh, Madan, Anup, Doyle, Laura, Harrabi, Ons, Kauder, Steven E., Chen, Amy, Kuo, Tracy C., Wan, Hong, Pons, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748616/
https://www.ncbi.nlm.nih.gov/pubmed/31257988
http://dx.doi.org/10.1080/19420862.2019.1624123

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