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Phytochemical treatments target kynurenine pathway induced oxidative stress
Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. Methods: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stres...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748679/ https://www.ncbi.nlm.nih.gov/pubmed/28651456 http://dx.doi.org/10.1080/13510002.2017.1343223 |
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author | Parasram, K. |
author_facet | Parasram, K. |
author_sort | Parasram, K. |
collection | PubMed |
description | Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. Methods: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stress associated with many neurological disorders and is used to simulate disorders such as Parkinson’s disease. Results: In these models, phytochemicals have been shown to reduce striatal lesion size, reduce inflammation and prevent lipid peroxidation caused by quinolinic acid. Conclusion: These results suggest that phenolic compounds, a class of phytochemicals, including flavonoids and diarylheptanoids, should be further studied to develop new treatments for oxidative stress related neurological disorders. |
format | Online Article Text |
id | pubmed-6748679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67486792020-04-15 Phytochemical treatments target kynurenine pathway induced oxidative stress Parasram, K. Redox Rep Review Article Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. Methods: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stress associated with many neurological disorders and is used to simulate disorders such as Parkinson’s disease. Results: In these models, phytochemicals have been shown to reduce striatal lesion size, reduce inflammation and prevent lipid peroxidation caused by quinolinic acid. Conclusion: These results suggest that phenolic compounds, a class of phytochemicals, including flavonoids and diarylheptanoids, should be further studied to develop new treatments for oxidative stress related neurological disorders. Taylor & Francis 2017-06-26 /pmc/articles/PMC6748679/ /pubmed/28651456 http://dx.doi.org/10.1080/13510002.2017.1343223 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Parasram, K. Phytochemical treatments target kynurenine pathway induced oxidative stress |
title | Phytochemical treatments target kynurenine pathway induced oxidative stress |
title_full | Phytochemical treatments target kynurenine pathway induced oxidative stress |
title_fullStr | Phytochemical treatments target kynurenine pathway induced oxidative stress |
title_full_unstemmed | Phytochemical treatments target kynurenine pathway induced oxidative stress |
title_short | Phytochemical treatments target kynurenine pathway induced oxidative stress |
title_sort | phytochemical treatments target kynurenine pathway induced oxidative stress |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748679/ https://www.ncbi.nlm.nih.gov/pubmed/28651456 http://dx.doi.org/10.1080/13510002.2017.1343223 |
work_keys_str_mv | AT parasramk phytochemicaltreatmentstargetkynureninepathwayinducedoxidativestress |