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Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention
BACKGROUND: There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. METHODS: A tot...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748900/ https://www.ncbi.nlm.nih.gov/pubmed/31555332 http://dx.doi.org/10.11909/j.issn.1671-5411.2019.08.006 |
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author | Kim, Yong Hoon Her, Ae-Young Rha, Seung-Woon Choi, Byoung Geol Choi, Se Yeon Byun, Jae Kyeong Park, Yoonjee Kang, Dong Oh Jang, Won Young Kim, Woohyeun Baek, Ju Yeol Choi, Woong Gil Kang, Tae Soo Ahn, Jihun Park, Sang-Ho Park, Ji Young Lee, Min-Ho Choi, Cheol Ung Park, Chang Gyu Seo, Hong Seog |
author_facet | Kim, Yong Hoon Her, Ae-Young Rha, Seung-Woon Choi, Byoung Geol Choi, Se Yeon Byun, Jae Kyeong Park, Yoonjee Kang, Dong Oh Jang, Won Young Kim, Woohyeun Baek, Ju Yeol Choi, Woong Gil Kang, Tae Soo Ahn, Jihun Park, Sang-Ho Park, Ji Young Lee, Min-Ho Choi, Cheol Ung Park, Chang Gyu Seo, Hong Seog |
author_sort | Kim, Yong Hoon |
collection | PubMed |
description | BACKGROUND: There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. METHODS: A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. RESULTS: After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. CONCLUSIONS: In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years. |
format | Online Article Text |
id | pubmed-6748900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-67489002019-09-25 Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention Kim, Yong Hoon Her, Ae-Young Rha, Seung-Woon Choi, Byoung Geol Choi, Se Yeon Byun, Jae Kyeong Park, Yoonjee Kang, Dong Oh Jang, Won Young Kim, Woohyeun Baek, Ju Yeol Choi, Woong Gil Kang, Tae Soo Ahn, Jihun Park, Sang-Ho Park, Ji Young Lee, Min-Ho Choi, Cheol Ung Park, Chang Gyu Seo, Hong Seog J Geriatr Cardiol Research Article BACKGROUND: There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. METHODS: A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. RESULTS: After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. CONCLUSIONS: In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years. Science Press 2019-08 /pmc/articles/PMC6748900/ /pubmed/31555332 http://dx.doi.org/10.11909/j.issn.1671-5411.2019.08.006 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Research Article Kim, Yong Hoon Her, Ae-Young Rha, Seung-Woon Choi, Byoung Geol Choi, Se Yeon Byun, Jae Kyeong Park, Yoonjee Kang, Dong Oh Jang, Won Young Kim, Woohyeun Baek, Ju Yeol Choi, Woong Gil Kang, Tae Soo Ahn, Jihun Park, Sang-Ho Park, Ji Young Lee, Min-Ho Choi, Cheol Ung Park, Chang Gyu Seo, Hong Seog Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
title | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
title_full | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
title_fullStr | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
title_full_unstemmed | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
title_short | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
title_sort | five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748900/ https://www.ncbi.nlm.nih.gov/pubmed/31555332 http://dx.doi.org/10.11909/j.issn.1671-5411.2019.08.006 |
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