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Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery

Hollow titanium dioxide (TiO(2)) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO(2) nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance an...

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Autores principales: Hasanzadeh Kafshgari, Morteza, Kah, Delf, Mazare, Anca, Nguyen, Nhat Truong, Distaso, Monica, Peukert, Wolfgang, Goldmann, Wolfgang H., Schmuki, Patrik, Fabry, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748954/
https://www.ncbi.nlm.nih.gov/pubmed/31530838
http://dx.doi.org/10.1038/s41598-019-49513-2
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author Hasanzadeh Kafshgari, Morteza
Kah, Delf
Mazare, Anca
Nguyen, Nhat Truong
Distaso, Monica
Peukert, Wolfgang
Goldmann, Wolfgang H.
Schmuki, Patrik
Fabry, Ben
author_facet Hasanzadeh Kafshgari, Morteza
Kah, Delf
Mazare, Anca
Nguyen, Nhat Truong
Distaso, Monica
Peukert, Wolfgang
Goldmann, Wolfgang H.
Schmuki, Patrik
Fabry, Ben
author_sort Hasanzadeh Kafshgari, Morteza
collection PubMed
description Hollow titanium dioxide (TiO(2)) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO(2) nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO(2) nanotubes (TiO(2)NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO(2) nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO(2)NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO(2)NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs.
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spelling pubmed-67489542019-09-27 Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery Hasanzadeh Kafshgari, Morteza Kah, Delf Mazare, Anca Nguyen, Nhat Truong Distaso, Monica Peukert, Wolfgang Goldmann, Wolfgang H. Schmuki, Patrik Fabry, Ben Sci Rep Article Hollow titanium dioxide (TiO(2)) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO(2) nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO(2) nanotubes (TiO(2)NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO(2) nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO(2)NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO(2)NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs. Nature Publishing Group UK 2019-09-17 /pmc/articles/PMC6748954/ /pubmed/31530838 http://dx.doi.org/10.1038/s41598-019-49513-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hasanzadeh Kafshgari, Morteza
Kah, Delf
Mazare, Anca
Nguyen, Nhat Truong
Distaso, Monica
Peukert, Wolfgang
Goldmann, Wolfgang H.
Schmuki, Patrik
Fabry, Ben
Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
title Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
title_full Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
title_fullStr Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
title_full_unstemmed Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
title_short Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
title_sort anodic titanium dioxide nanotubes for magnetically guided therapeutic delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748954/
https://www.ncbi.nlm.nih.gov/pubmed/31530838
http://dx.doi.org/10.1038/s41598-019-49513-2
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