Lipoarabinomannan in Active and Passive Protection Against Tuberculosis

Glycolipids of the cell wall of Mycobacterium tuberculosis (Mtb) are important immunomodulators in tuberculosis. In particular, lipoarabinomannan (LAM) has a profound effect on the innate immune response. LAM and its structural variants can be recognized by and activate human CD1b-restricted T cells...

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Autores principales: Correia-Neves, Margarida, Sundling, Christopher, Cooper, Andrea, Källenius, Gunilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749014/
https://www.ncbi.nlm.nih.gov/pubmed/31572351
http://dx.doi.org/10.3389/fimmu.2019.01968
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author Correia-Neves, Margarida
Sundling, Christopher
Cooper, Andrea
Källenius, Gunilla
author_facet Correia-Neves, Margarida
Sundling, Christopher
Cooper, Andrea
Källenius, Gunilla
author_sort Correia-Neves, Margarida
collection PubMed
description Glycolipids of the cell wall of Mycobacterium tuberculosis (Mtb) are important immunomodulators in tuberculosis. In particular, lipoarabinomannan (LAM) has a profound effect on the innate immune response. LAM and its structural variants can be recognized by and activate human CD1b-restricted T cells, and emerging evidence indicates that B cells and antibodies against LAM can modulate the immune response to Mtb. Anti-LAM antibodies are induced during Mtb infection and after bacille Calmette–Guerin (BCG) vaccination, and monoclonal antibodies against LAM have been shown to confer protection by passive administration in mice and guinea pigs. In this review, we describe the immune response against LAM and the potential use of the mannose-capped arabinan moiety of LAM in the construction of vaccine candidates against tuberculosis.
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spelling pubmed-67490142019-09-30 Lipoarabinomannan in Active and Passive Protection Against Tuberculosis Correia-Neves, Margarida Sundling, Christopher Cooper, Andrea Källenius, Gunilla Front Immunol Immunology Glycolipids of the cell wall of Mycobacterium tuberculosis (Mtb) are important immunomodulators in tuberculosis. In particular, lipoarabinomannan (LAM) has a profound effect on the innate immune response. LAM and its structural variants can be recognized by and activate human CD1b-restricted T cells, and emerging evidence indicates that B cells and antibodies against LAM can modulate the immune response to Mtb. Anti-LAM antibodies are induced during Mtb infection and after bacille Calmette–Guerin (BCG) vaccination, and monoclonal antibodies against LAM have been shown to confer protection by passive administration in mice and guinea pigs. In this review, we describe the immune response against LAM and the potential use of the mannose-capped arabinan moiety of LAM in the construction of vaccine candidates against tuberculosis. Frontiers Media S.A. 2019-09-11 /pmc/articles/PMC6749014/ /pubmed/31572351 http://dx.doi.org/10.3389/fimmu.2019.01968 Text en Copyright © 2019 Correia-Neves, Sundling, Cooper and Källenius. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Correia-Neves, Margarida
Sundling, Christopher
Cooper, Andrea
Källenius, Gunilla
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
title Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
title_full Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
title_fullStr Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
title_full_unstemmed Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
title_short Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
title_sort lipoarabinomannan in active and passive protection against tuberculosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749014/
https://www.ncbi.nlm.nih.gov/pubmed/31572351
http://dx.doi.org/10.3389/fimmu.2019.01968
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