Cargando…

Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis

Hepatocyte growth factor (HGF) and its receptor, cMet, activate biological pathways necessary for repair and regeneration following kidney injury. Because HGF is a highly unstable molecule in its biologically active form, we asked whether a monoclonal antibody (Ab) that displays full agonist activit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Yong Chul, Lee, Junghun, An, Jung Nam, Kim, Jin Hyuk, Choi, Young-Wook, Li, Lilin, Kwon, Sang Ho, Lee, Mi-Young, Lee, Boeun, Jeong, Jae-Gyun, Yu, Seung-Shin, Lim, Chun Soo, Kim, Yon Su, Kim, Sunyoung, Yang, Seung Hee, Lee, Jung Pyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749055/ https://www.ncbi.nlm.nih.gov/pubmed/31530851 http://dx.doi.org/10.1038/s41598-019-49756-z

Ejemplares similares

cMet agonistic antibody attenuates apoptosis in ischaemia‐reperfusion–induced kidney injury
por: An, Jung Nam, et al.
Publicado: (2020)

Urinary cMet as a prognostic marker in immunoglobulin A nephropathy
por: An, Jung Nam, et al.
Publicado: (2020)

Soluble cMet levels in urine are a significant prognostic biomarker for diabetic nephropathy
por: Kim, Yong Chul, et al.
Publicado: (2018)

Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury
por: Li, Lilin, et al.
Publicado: (2021)

Impairment of peripheral nerve regeneration by insufficient activation of the HGF/c-Met/c-Jun pathway in aged mice
por: Lee, Nayeon, et al.
Publicado: (2022)

Progress of antibody-based inhibitors of the HGF–cMET axis in cancer therapy
por: Kim, Ki-Hyun, et al.
Publicado: (2017)

Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma
por: Lohberger, Birgit, et al.
Publicado: (2021)

Targeting the HGF-cMET Axis in Hepatocellular Carcinoma
por: Venepalli, Neeta K., et al.
Publicado: (2013)

Role of cMET in the Development and Progression of Colorectal Cancer
por: Pérez-Vargas, Juan Carlos Samamé, et al.
Publicado: (2013)

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status
por: Lee, Jeeyun, et al.
Publicado: (2014)

The Role of cMET in Gastric Cancer—A Review of the Literature
por: Van Herpe, Filip, et al.
Publicado: (2023)

cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer
por: Sohn, Joohyuk, et al.
Publicado: (2014)

Characterization of an oncolytic adenovirus vector constructed to target the cMet receptor
por: Sakr, Hany I, et al.
Publicado: (2015)

Optimal Proteinuria Target for Renoprotection in Patients with IgA Nephropathy
por: Nam, Ki Heon, et al.
Publicado: (2014)

Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet
por: Wu, Xiaoli, et al.
Publicado: (2019)

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors
por: Collie, Gavin W., et al.
Publicado: (2019)

Dual Targeting of CDK4/6 and cMET in Metastatic Uveal Melanoma
por: Ohara, Masahiro, et al.
Publicado: (2021)

The utility of cMet as a diagnostic tissue biomarker in primary colorectal cancer
por: Armstrong, Gemma R., et al.
Publicado: (2021)

Targeting the cMET pathway to enhance immunotherapeutic approaches for mUM patients
por: Machiraju, Devayani, et al.
Publicado: (2023)

Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy
por: Bae, Eunjin, et al.
Publicado: (2022)

Active maintenance of endothelial cells prevents kidney fibrosis
por: Yang, Seung Hee, et al.
Publicado: (2017)

Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models
por: Lee, Sang Hwan, et al.
Publicado: (2019)

Construction of Plasmid DNA Expressing Two Isoforms of Insulin-Like Growth Factor-1 and Its Effects on Skeletal Muscle Injury Models
por: Lee, Jaeman, et al.
Publicado: (2022)

The Association between EGFR and cMET Expression and Phosphorylation and Its Prognostic Implication in Patients with Breast Cancer
por: Chae, Young Kwang, et al.
Publicado: (2016)

Effects of periostin deficiency on kidney aging and lipid metabolism
por: An, Jung Nam, et al.
Publicado: (2021)

Hepatocyte growth factor is necessary for efficient outgrowth of injured peripheral axons in in vitro culture system and in vivo nerve crush mouse model
por: Lee, Nayeon, et al.
Publicado: (2021)

cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance
por: Van Der Steen, Nele, et al.
Publicado: (2015)

Non‐canonical cMet regulation by vimentin mediates Plk1 inhibitor–induced apoptosis
por: Singh, Ratnakar, et al.
Publicado: (2019)

EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming
por: Meng, Fanyan, et al.
Publicado: (2019)

The levels of soluble cMET ectodomain in the blood of patients with ovarian cancer are an independent prognostic biomarker
por: Klotz, Daniel Martin, et al.
Publicado: (2021)

Factors Affecting the Referral Time to Nephrologists in Patients With Chronic Kidney Disease: A Prospective Cohort Study in Korea
por: Lee, Jeonghwan, et al.
Publicado: (2016)

Elevated bilirubin levels are associated with a better renal prognosis and ameliorate kidney fibrosis
por: Park, Sehoon, et al.
Publicado: (2017)

The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
por: Spiegelberg, Diana, et al.
Publicado: (2020)

An independent validation of the kidney failure risk equation in an Asian population
por: Kang, Min Woo, et al.
Publicado: (2020)

Renoprotective Mechanism of Remote Ischemic Preconditioning Based on Transcriptomic Analysis in a Porcine Renal Ischemia Reperfusion Injury Model
por: Yoon, Young Eun, et al.
Publicado: (2015)

Physician perceptions of blood pressure control in patients with chronic kidney disease and target blood pressure achievement rate
por: Cha, Ran-hui, et al.
Publicado: (2017)

Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats
por: Kim, Seung Hyun, et al.
Publicado: (2018)

Efficacy and Safety of Ghrelin Agonists in Patients with Diabetic Gastroparesis: A Systematic Review and Meta-Analysis
por: Hong, Seung Wook, et al.
Publicado: (2020)

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats
por: Lee, Junghun, et al.
Publicado: (2018)

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
por: Vengoji, Raghupathy, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3jfed9qt5l61e82tk54aiersdh