Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef–AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells

Current combined antiretroviral therapy (cART) mainly targets 3 of the 15 HIV proteins leaving many potential viral vulnerabilities unexploited. To purge the HIV-1 latent reservoir, various strategies including “shock and kill” have been developed. A key question is how to restore impaired immune su...

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Detalles Bibliográficos
Autores principales: Liu, Bingfeng, Zhang, Xu, Zhang, Wanying, Wu, Liyang, Jing, Shuliang, Liu, Weiwei, Xia, Baijin, Zou, Fan, Lu, Lijuan, Ma, Xiancai, He, Dalian, Hu, Qifei, Zhang, Yiwen, Deng, Kai, Cai, Weiping, Tang, Xiaoping, Peng, Tao, Zhang, Hui, Li, Linghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749138/
https://www.ncbi.nlm.nih.gov/pubmed/31572371
http://dx.doi.org/10.3389/fimmu.2019.02151

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