Cargando…
Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals
Air pollution is a global threat to human health especially spermatogenesis. Animal and epidemiological studies suggest that epigenetic factors can transmit the pathologies transgenerationally. Paternal epigenetic effects can greatly impact offspring health. In this study and together with our previ...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749155/ https://www.ncbi.nlm.nih.gov/pubmed/31572187 http://dx.doi.org/10.3389/fphar.2019.01012 |
_version_ | 1783452215659200512 |
---|---|
author | Han, Xiao Zhang, Pengfei Shen, Wei Zhao, Yong Zhang, Hongfu |
author_facet | Han, Xiao Zhang, Pengfei Shen, Wei Zhao, Yong Zhang, Hongfu |
author_sort | Han, Xiao |
collection | PubMed |
description | Air pollution is a global threat to human health especially spermatogenesis. Animal and epidemiological studies suggest that epigenetic factors can transmit the pathologies transgenerationally. Paternal epigenetic effects can greatly impact offspring health. In this study and together with our previous report, we found that H(2)S donor Na(2)S and/or NH(3) donor NH(4)Cl diminished mouse fertility, decreased spermatozoa concentration and motility, and impaired spermatogenesis in three consequent generations (F0, F1, and F2). In the current study, we found that DNA methylation, histone methylation, and estrogen receptor alpha (ERα) were impaired by NH(4)Cl and/or Na(2)S in F0, F1, and F2 mouse testes. Moreover, NH(4)Cl and/or Na(2)S might act as environmental endocrine-disrupting chemicals to decrease estrogen and testosterone in mouse blood. It has been reported that ERα signaling is intertwined together with DNA methylation and histone methylation, which plays very important roles in spermatogenesis. These data together indicate that the transgenerational disruption in spermatogenesis by NH(4)Cl and/or Na(2)S may be through ERα-related DNA methylation and histone methylation pathways. Therefore, we strongly recommend that greater attention should be paid to NH(3) and/or H(2)S contamination to minimize their impact on human health especially spermatogenesis. |
format | Online Article Text |
id | pubmed-6749155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67491552019-09-30 Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals Han, Xiao Zhang, Pengfei Shen, Wei Zhao, Yong Zhang, Hongfu Front Pharmacol Pharmacology Air pollution is a global threat to human health especially spermatogenesis. Animal and epidemiological studies suggest that epigenetic factors can transmit the pathologies transgenerationally. Paternal epigenetic effects can greatly impact offspring health. In this study and together with our previous report, we found that H(2)S donor Na(2)S and/or NH(3) donor NH(4)Cl diminished mouse fertility, decreased spermatozoa concentration and motility, and impaired spermatogenesis in three consequent generations (F0, F1, and F2). In the current study, we found that DNA methylation, histone methylation, and estrogen receptor alpha (ERα) were impaired by NH(4)Cl and/or Na(2)S in F0, F1, and F2 mouse testes. Moreover, NH(4)Cl and/or Na(2)S might act as environmental endocrine-disrupting chemicals to decrease estrogen and testosterone in mouse blood. It has been reported that ERα signaling is intertwined together with DNA methylation and histone methylation, which plays very important roles in spermatogenesis. These data together indicate that the transgenerational disruption in spermatogenesis by NH(4)Cl and/or Na(2)S may be through ERα-related DNA methylation and histone methylation pathways. Therefore, we strongly recommend that greater attention should be paid to NH(3) and/or H(2)S contamination to minimize their impact on human health especially spermatogenesis. Frontiers Media S.A. 2019-09-11 /pmc/articles/PMC6749155/ /pubmed/31572187 http://dx.doi.org/10.3389/fphar.2019.01012 Text en Copyright © 2019 Han, Zhang, Shen, Zhao and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Han, Xiao Zhang, Pengfei Shen, Wei Zhao, Yong Zhang, Hongfu Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals |
title | Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals |
title_full | Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals |
title_fullStr | Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals |
title_full_unstemmed | Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals |
title_short | Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals |
title_sort | estrogen receptor-related dna and histone methylation may be involved in the transgenerational disruption in spermatogenesis by selective toxic chemicals |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749155/ https://www.ncbi.nlm.nih.gov/pubmed/31572187 http://dx.doi.org/10.3389/fphar.2019.01012 |
work_keys_str_mv | AT hanxiao estrogenreceptorrelateddnaandhistonemethylationmaybeinvolvedinthetransgenerationaldisruptioninspermatogenesisbyselectivetoxicchemicals AT zhangpengfei estrogenreceptorrelateddnaandhistonemethylationmaybeinvolvedinthetransgenerationaldisruptioninspermatogenesisbyselectivetoxicchemicals AT shenwei estrogenreceptorrelateddnaandhistonemethylationmaybeinvolvedinthetransgenerationaldisruptioninspermatogenesisbyselectivetoxicchemicals AT zhaoyong estrogenreceptorrelateddnaandhistonemethylationmaybeinvolvedinthetransgenerationaldisruptioninspermatogenesisbyselectivetoxicchemicals AT zhanghongfu estrogenreceptorrelateddnaandhistonemethylationmaybeinvolvedinthetransgenerationaldisruptioninspermatogenesisbyselectivetoxicchemicals |