The Involvement and Therapy Target of Immune Cells After Ischemic Stroke

After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages, infiltrate into the ischemic brain tissue and play an important role in regulating the progression of ischemic brain inj...

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Autores principales: Jian, Zhihong, Liu, Rui, Zhu, Xiqun, Smerin, Daniel, Zhong, Yi, Gu, Lijuan, Fang, Weirong, Xiong, Xiaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749156/
https://www.ncbi.nlm.nih.gov/pubmed/31572378
http://dx.doi.org/10.3389/fimmu.2019.02167
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author Jian, Zhihong
Liu, Rui
Zhu, Xiqun
Smerin, Daniel
Zhong, Yi
Gu, Lijuan
Fang, Weirong
Xiong, Xiaoxing
author_facet Jian, Zhihong
Liu, Rui
Zhu, Xiqun
Smerin, Daniel
Zhong, Yi
Gu, Lijuan
Fang, Weirong
Xiong, Xiaoxing
author_sort Jian, Zhihong
collection PubMed
description After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages, infiltrate into the ischemic brain tissue and play an important role in regulating the progression of ischemic brain injury. In this review, we will discuss the role of different immune cells after stroke in the secondary inflammatory reaction and focus on the phenotypes and functions of macrophages in ischemic stroke, as well as briefly introduce the anti-ischemic stroke therapy targeting macrophages.
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spelling pubmed-67491562019-09-30 The Involvement and Therapy Target of Immune Cells After Ischemic Stroke Jian, Zhihong Liu, Rui Zhu, Xiqun Smerin, Daniel Zhong, Yi Gu, Lijuan Fang, Weirong Xiong, Xiaoxing Front Immunol Immunology After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages, infiltrate into the ischemic brain tissue and play an important role in regulating the progression of ischemic brain injury. In this review, we will discuss the role of different immune cells after stroke in the secondary inflammatory reaction and focus on the phenotypes and functions of macrophages in ischemic stroke, as well as briefly introduce the anti-ischemic stroke therapy targeting macrophages. Frontiers Media S.A. 2019-09-11 /pmc/articles/PMC6749156/ /pubmed/31572378 http://dx.doi.org/10.3389/fimmu.2019.02167 Text en Copyright © 2019 Jian, Liu, Zhu, Smerin, Zhong, Gu, Fang and Xiong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jian, Zhihong
Liu, Rui
Zhu, Xiqun
Smerin, Daniel
Zhong, Yi
Gu, Lijuan
Fang, Weirong
Xiong, Xiaoxing
The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
title The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
title_full The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
title_fullStr The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
title_full_unstemmed The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
title_short The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
title_sort involvement and therapy target of immune cells after ischemic stroke
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749156/
https://www.ncbi.nlm.nih.gov/pubmed/31572378
http://dx.doi.org/10.3389/fimmu.2019.02167
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