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The Rise of Coccidioides: Forces Against the Dust Devil Unleashed

Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomy...

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Autores principales: Van Dyke, Marley C. Caballero, Thompson, George R., Galgiani, John N., Barker, Bridget M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749157/
https://www.ncbi.nlm.nih.gov/pubmed/31572393
http://dx.doi.org/10.3389/fimmu.2019.02188
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author Van Dyke, Marley C. Caballero
Thompson, George R.
Galgiani, John N.
Barker, Bridget M.
author_facet Van Dyke, Marley C. Caballero
Thompson, George R.
Galgiani, John N.
Barker, Bridget M.
author_sort Van Dyke, Marley C. Caballero
collection PubMed
description Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to severe pulmonary disease and can disseminate to the brain, skin, bones, and elsewhere. New estimates suggest as many as 350,000 new cases of coccidioidomycosis occur in the United States each year. Thus, there is an urgent need for the development of a vaccine and new therapeutic drugs against Coccidioides infection. In this review, we discuss the battle against Coccidioides including the development of potential vaccines, the quest for new therapeutic drugs, and our current understanding of the protective host immune response to Coccidioides infection.
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spelling pubmed-67491572019-09-30 The Rise of Coccidioides: Forces Against the Dust Devil Unleashed Van Dyke, Marley C. Caballero Thompson, George R. Galgiani, John N. Barker, Bridget M. Front Immunol Immunology Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to severe pulmonary disease and can disseminate to the brain, skin, bones, and elsewhere. New estimates suggest as many as 350,000 new cases of coccidioidomycosis occur in the United States each year. Thus, there is an urgent need for the development of a vaccine and new therapeutic drugs against Coccidioides infection. In this review, we discuss the battle against Coccidioides including the development of potential vaccines, the quest for new therapeutic drugs, and our current understanding of the protective host immune response to Coccidioides infection. Frontiers Media S.A. 2019-09-11 /pmc/articles/PMC6749157/ /pubmed/31572393 http://dx.doi.org/10.3389/fimmu.2019.02188 Text en Copyright © 2019 Van Dyke, Thompson, Galgiani and Barker. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Van Dyke, Marley C. Caballero
Thompson, George R.
Galgiani, John N.
Barker, Bridget M.
The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
title The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
title_full The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
title_fullStr The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
title_full_unstemmed The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
title_short The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
title_sort rise of coccidioides: forces against the dust devil unleashed
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749157/
https://www.ncbi.nlm.nih.gov/pubmed/31572393
http://dx.doi.org/10.3389/fimmu.2019.02188
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