Cargando…
The Rise of Coccidioides: Forces Against the Dust Devil Unleashed
Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomy...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749157/ https://www.ncbi.nlm.nih.gov/pubmed/31572393 http://dx.doi.org/10.3389/fimmu.2019.02188 |
_version_ | 1783452216116379648 |
---|---|
author | Van Dyke, Marley C. Caballero Thompson, George R. Galgiani, John N. Barker, Bridget M. |
author_facet | Van Dyke, Marley C. Caballero Thompson, George R. Galgiani, John N. Barker, Bridget M. |
author_sort | Van Dyke, Marley C. Caballero |
collection | PubMed |
description | Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to severe pulmonary disease and can disseminate to the brain, skin, bones, and elsewhere. New estimates suggest as many as 350,000 new cases of coccidioidomycosis occur in the United States each year. Thus, there is an urgent need for the development of a vaccine and new therapeutic drugs against Coccidioides infection. In this review, we discuss the battle against Coccidioides including the development of potential vaccines, the quest for new therapeutic drugs, and our current understanding of the protective host immune response to Coccidioides infection. |
format | Online Article Text |
id | pubmed-6749157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67491572019-09-30 The Rise of Coccidioides: Forces Against the Dust Devil Unleashed Van Dyke, Marley C. Caballero Thompson, George R. Galgiani, John N. Barker, Bridget M. Front Immunol Immunology Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to severe pulmonary disease and can disseminate to the brain, skin, bones, and elsewhere. New estimates suggest as many as 350,000 new cases of coccidioidomycosis occur in the United States each year. Thus, there is an urgent need for the development of a vaccine and new therapeutic drugs against Coccidioides infection. In this review, we discuss the battle against Coccidioides including the development of potential vaccines, the quest for new therapeutic drugs, and our current understanding of the protective host immune response to Coccidioides infection. Frontiers Media S.A. 2019-09-11 /pmc/articles/PMC6749157/ /pubmed/31572393 http://dx.doi.org/10.3389/fimmu.2019.02188 Text en Copyright © 2019 Van Dyke, Thompson, Galgiani and Barker. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Van Dyke, Marley C. Caballero Thompson, George R. Galgiani, John N. Barker, Bridget M. The Rise of Coccidioides: Forces Against the Dust Devil Unleashed |
title | The Rise of Coccidioides: Forces Against the Dust Devil Unleashed |
title_full | The Rise of Coccidioides: Forces Against the Dust Devil Unleashed |
title_fullStr | The Rise of Coccidioides: Forces Against the Dust Devil Unleashed |
title_full_unstemmed | The Rise of Coccidioides: Forces Against the Dust Devil Unleashed |
title_short | The Rise of Coccidioides: Forces Against the Dust Devil Unleashed |
title_sort | rise of coccidioides: forces against the dust devil unleashed |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749157/ https://www.ncbi.nlm.nih.gov/pubmed/31572393 http://dx.doi.org/10.3389/fimmu.2019.02188 |
work_keys_str_mv | AT vandykemarleyccaballero theriseofcoccidioidesforcesagainstthedustdevilunleashed AT thompsongeorger theriseofcoccidioidesforcesagainstthedustdevilunleashed AT galgianijohnn theriseofcoccidioidesforcesagainstthedustdevilunleashed AT barkerbridgetm theriseofcoccidioidesforcesagainstthedustdevilunleashed AT vandykemarleyccaballero riseofcoccidioidesforcesagainstthedustdevilunleashed AT thompsongeorger riseofcoccidioidesforcesagainstthedustdevilunleashed AT galgianijohnn riseofcoccidioidesforcesagainstthedustdevilunleashed AT barkerbridgetm riseofcoccidioidesforcesagainstthedustdevilunleashed |