Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules

Iodonium(III) salts bearing uracil moieties have recently appeared in the literature, but their structural scope and utilization are limited because of their hygroscopic characteristics. In this study, we describe our detailed investigations for synthesizing a series of uracil iodonium(III) salts de...

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Autores principales: Takenaga, Naoko, Hayashi, Takumi, Ueda, Shohei, Satake, Hiroyuki, Yamada, Yoichi, Kodama, Tetsuya, Dohi, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749211/
https://www.ncbi.nlm.nih.gov/pubmed/31438596
http://dx.doi.org/10.3390/molecules24173034
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author Takenaga, Naoko
Hayashi, Takumi
Ueda, Shohei
Satake, Hiroyuki
Yamada, Yoichi
Kodama, Tetsuya
Dohi, Toshifumi
author_facet Takenaga, Naoko
Hayashi, Takumi
Ueda, Shohei
Satake, Hiroyuki
Yamada, Yoichi
Kodama, Tetsuya
Dohi, Toshifumi
author_sort Takenaga, Naoko
collection PubMed
description Iodonium(III) salts bearing uracil moieties have recently appeared in the literature, but their structural scope and utilization are limited because of their hygroscopic characteristics. In this study, we describe our detailed investigations for synthesizing a series of uracil iodonium(III) salts derived with various structural motifs and counterions. These new compounds have been utilized as attractive synthetic modules in constructing functionalized nucleobase and nucleosides.
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spelling pubmed-67492112019-09-27 Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules Takenaga, Naoko Hayashi, Takumi Ueda, Shohei Satake, Hiroyuki Yamada, Yoichi Kodama, Tetsuya Dohi, Toshifumi Molecules Article Iodonium(III) salts bearing uracil moieties have recently appeared in the literature, but their structural scope and utilization are limited because of their hygroscopic characteristics. In this study, we describe our detailed investigations for synthesizing a series of uracil iodonium(III) salts derived with various structural motifs and counterions. These new compounds have been utilized as attractive synthetic modules in constructing functionalized nucleobase and nucleosides. MDPI 2019-08-21 /pmc/articles/PMC6749211/ /pubmed/31438596 http://dx.doi.org/10.3390/molecules24173034 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takenaga, Naoko
Hayashi, Takumi
Ueda, Shohei
Satake, Hiroyuki
Yamada, Yoichi
Kodama, Tetsuya
Dohi, Toshifumi
Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
title Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
title_full Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
title_fullStr Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
title_full_unstemmed Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
title_short Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
title_sort synthesis of uracil-iodonium(iii) salts for practical utilization as nucleobase synthetic modules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749211/
https://www.ncbi.nlm.nih.gov/pubmed/31438596
http://dx.doi.org/10.3390/molecules24173034
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