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The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells

Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Huma...

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Autores principales: He, Yuzhu, Kim, Byung-gook, Kim, Hye-Eun, Sun, Qiaochu, Shi, Shuhan, Ma, Guowu, Kim, Young, Kim, Ok-su, Kim, Ok-joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749254/
https://www.ncbi.nlm.nih.gov/pubmed/31443581
http://dx.doi.org/10.3390/molecules24173064
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author He, Yuzhu
Kim, Byung-gook
Kim, Hye-Eun
Sun, Qiaochu
Shi, Shuhan
Ma, Guowu
Kim, Young
Kim, Ok-su
Kim, Ok-joon
author_facet He, Yuzhu
Kim, Byung-gook
Kim, Hye-Eun
Sun, Qiaochu
Shi, Shuhan
Ma, Guowu
Kim, Young
Kim, Ok-su
Kim, Ok-joon
author_sort He, Yuzhu
collection PubMed
description Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Human epidermis mainly comprises keratinocytes whose inflammation causes skin problems. This study investigated the protective effects of FS on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. The mechanism was investigated by analyzing cell viability, PGE(2) levels, cell apoptosis, nuclear factor erythroid 2-related factor 2 (Nrf2) translocation, and TLR4/NF-κB pathway. The anti-inflammatory effects of FS were assessed by inhibiting the inflammation via down-regulating the TLR4/NF-κB pathway. Additionally, FS promoted Nrf2 translocation to the nucleus, indicating that FS showed anti-oxidative activities. Furthermore, the antioxidative and anti-inflammatory effects of FS were found to benefit each other, but were independent. Thus, FS can be used as a component to manage epidermal inflammation due to its anti-inflammatory and anti-oxidative properties.
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spelling pubmed-67492542019-09-27 The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells He, Yuzhu Kim, Byung-gook Kim, Hye-Eun Sun, Qiaochu Shi, Shuhan Ma, Guowu Kim, Young Kim, Ok-su Kim, Ok-joon Molecules Article Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Human epidermis mainly comprises keratinocytes whose inflammation causes skin problems. This study investigated the protective effects of FS on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. The mechanism was investigated by analyzing cell viability, PGE(2) levels, cell apoptosis, nuclear factor erythroid 2-related factor 2 (Nrf2) translocation, and TLR4/NF-κB pathway. The anti-inflammatory effects of FS were assessed by inhibiting the inflammation via down-regulating the TLR4/NF-κB pathway. Additionally, FS promoted Nrf2 translocation to the nucleus, indicating that FS showed anti-oxidative activities. Furthermore, the antioxidative and anti-inflammatory effects of FS were found to benefit each other, but were independent. Thus, FS can be used as a component to manage epidermal inflammation due to its anti-inflammatory and anti-oxidative properties. MDPI 2019-08-23 /pmc/articles/PMC6749254/ /pubmed/31443581 http://dx.doi.org/10.3390/molecules24173064 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Yuzhu
Kim, Byung-gook
Kim, Hye-Eun
Sun, Qiaochu
Shi, Shuhan
Ma, Guowu
Kim, Young
Kim, Ok-su
Kim, Ok-joon
The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells
title The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells
title_full The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells
title_fullStr The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells
title_full_unstemmed The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells
title_short The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells
title_sort protective role of feruloylserotonin in lps-induced hacat cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749254/
https://www.ncbi.nlm.nih.gov/pubmed/31443581
http://dx.doi.org/10.3390/molecules24173064
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