Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.

Two new indolizidine alkaloids, crepidatumines C (1) and D (2), together with crepidine (3), isocrepidamine (4), and crepidamine (5) were isolated from the Dendrobium crepidatum Lindl. ex Paxt. X-ray diffraction experiments established the absolute configurations of known compounds 3 and 4. The plan...

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Autores principales: Xu, Xiaolin, Li, Zesheng, Yang, Runmei, Zhou, Houguang, Bai, Yanbin, Yu, Meng, Ding, Gang, Li, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749285/
https://www.ncbi.nlm.nih.gov/pubmed/31450800
http://dx.doi.org/10.3390/molecules24173071
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author Xu, Xiaolin
Li, Zesheng
Yang, Runmei
Zhou, Houguang
Bai, Yanbin
Yu, Meng
Ding, Gang
Li, Biao
author_facet Xu, Xiaolin
Li, Zesheng
Yang, Runmei
Zhou, Houguang
Bai, Yanbin
Yu, Meng
Ding, Gang
Li, Biao
author_sort Xu, Xiaolin
collection PubMed
description Two new indolizidine alkaloids, crepidatumines C (1) and D (2), together with crepidine (3), isocrepidamine (4), and crepidamine (5) were isolated from the Dendrobium crepidatum Lindl. ex Paxt. X-ray diffraction experiments established the absolute configurations of known compounds 3 and 4. The planar structures and relative configurations of new compounds 1 and 2 were elucidated by extensive spectra analysis including HR-ESI-MS, NMR ((1)H, (13)C, (1)H-(1)H COSY, HSQC, HMBC, and NOESY spectra), and the absolute configurations of 1 and 2 were suggested on the basis of possible biosynthetic pathways. The biological results confirmed that isocrepidamine (4) displayed a potent hypoglycemic effect in vitro without cytotoxicity.
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spelling pubmed-67492852019-09-27 Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt. Xu, Xiaolin Li, Zesheng Yang, Runmei Zhou, Houguang Bai, Yanbin Yu, Meng Ding, Gang Li, Biao Molecules Article Two new indolizidine alkaloids, crepidatumines C (1) and D (2), together with crepidine (3), isocrepidamine (4), and crepidamine (5) were isolated from the Dendrobium crepidatum Lindl. ex Paxt. X-ray diffraction experiments established the absolute configurations of known compounds 3 and 4. The planar structures and relative configurations of new compounds 1 and 2 were elucidated by extensive spectra analysis including HR-ESI-MS, NMR ((1)H, (13)C, (1)H-(1)H COSY, HSQC, HMBC, and NOESY spectra), and the absolute configurations of 1 and 2 were suggested on the basis of possible biosynthetic pathways. The biological results confirmed that isocrepidamine (4) displayed a potent hypoglycemic effect in vitro without cytotoxicity. MDPI 2019-08-23 /pmc/articles/PMC6749285/ /pubmed/31450800 http://dx.doi.org/10.3390/molecules24173071 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xiaolin
Li, Zesheng
Yang, Runmei
Zhou, Houguang
Bai, Yanbin
Yu, Meng
Ding, Gang
Li, Biao
Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.
title Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.
title_full Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.
title_fullStr Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.
title_full_unstemmed Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.
title_short Crepidatumines C and D, Two New Indolizidine Alkaloids from Dendrobium crepidatum Lindl. ex Paxt.
title_sort crepidatumines c and d, two new indolizidine alkaloids from dendrobium crepidatum lindl. ex paxt.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749285/
https://www.ncbi.nlm.nih.gov/pubmed/31450800
http://dx.doi.org/10.3390/molecules24173071
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