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Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin

A novel synthetic strategy for obtainment of (±)-3-deoxyradicinin (2) is reported. This synthetic methodology is more efficient than those previously reported in the literature and also shows higher versatility towards the introduction of different side-chains at both C-7 and C-2. The obtained compo...

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Autores principales: Marsico, Giulia, Ciccone, Maria Sabrina, Masi, Marco, Freda, Fabrizio, Cristofaro, Massimo, Evidente, Antonio, Superchi, Stefano, Scafato, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749313/
https://www.ncbi.nlm.nih.gov/pubmed/31484319
http://dx.doi.org/10.3390/molecules24173193
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author Marsico, Giulia
Ciccone, Maria Sabrina
Masi, Marco
Freda, Fabrizio
Cristofaro, Massimo
Evidente, Antonio
Superchi, Stefano
Scafato, Patrizia
author_facet Marsico, Giulia
Ciccone, Maria Sabrina
Masi, Marco
Freda, Fabrizio
Cristofaro, Massimo
Evidente, Antonio
Superchi, Stefano
Scafato, Patrizia
author_sort Marsico, Giulia
collection PubMed
description A novel synthetic strategy for obtainment of (±)-3-deoxyradicinin (2) is reported. This synthetic methodology is more efficient than those previously reported in the literature and also shows higher versatility towards the introduction of different side-chains at both C-7 and C-2. The obtained compound (±)-2 shows phytotoxicity against the grass-weed buffelgrass comparable to that of the natural phytotoxin radicinin (1). Therefore, (±)-2 can constitute a more practical synthetic alternative to 1 as bioherbicide for buffelgrass control.
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spelling pubmed-67493132019-09-27 Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin Marsico, Giulia Ciccone, Maria Sabrina Masi, Marco Freda, Fabrizio Cristofaro, Massimo Evidente, Antonio Superchi, Stefano Scafato, Patrizia Molecules Article A novel synthetic strategy for obtainment of (±)-3-deoxyradicinin (2) is reported. This synthetic methodology is more efficient than those previously reported in the literature and also shows higher versatility towards the introduction of different side-chains at both C-7 and C-2. The obtained compound (±)-2 shows phytotoxicity against the grass-weed buffelgrass comparable to that of the natural phytotoxin radicinin (1). Therefore, (±)-2 can constitute a more practical synthetic alternative to 1 as bioherbicide for buffelgrass control. MDPI 2019-09-03 /pmc/articles/PMC6749313/ /pubmed/31484319 http://dx.doi.org/10.3390/molecules24173193 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marsico, Giulia
Ciccone, Maria Sabrina
Masi, Marco
Freda, Fabrizio
Cristofaro, Massimo
Evidente, Antonio
Superchi, Stefano
Scafato, Patrizia
Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin
title Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin
title_full Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin
title_fullStr Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin
title_full_unstemmed Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin
title_short Synthesis and Herbicidal Activity Against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin
title_sort synthesis and herbicidal activity against buffelgrass (cenchrus ciliaris) of (±)-3-deoxyradicinin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749313/
https://www.ncbi.nlm.nih.gov/pubmed/31484319
http://dx.doi.org/10.3390/molecules24173193
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