Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum

Sixteen new prenylated flavonoids, sinoflavonoids P–Z (1–11) and sinoflavonoids NA–NE (12–16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17–24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, (1)H-NMR, (13)...

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Detalles Bibliográficos
Autores principales: Sun, Yanjun, Chen, Haojie, Wang, Junmin, Gao, Meiling, Zhao, Chen, Han, Ruijie, Chen, Hui, Li, Meng, Xue, Guimin, Feng, Weisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749350/
https://www.ncbi.nlm.nih.gov/pubmed/31484370
http://dx.doi.org/10.3390/molecules24173196
Descripción
Sumario:Sixteen new prenylated flavonoids, sinoflavonoids P–Z (1–11) and sinoflavonoids NA–NE (12–16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17–24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, (1)H-NMR, (13)C-NMR, HSQC, HMBC). The cytotoxic activities of compounds 1–18, 20, and 22 were evaluated by MTT assay. Compound 6 showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC(50) values of 6.25 and 3.83 μM, respectively.

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