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Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum

Sixteen new prenylated flavonoids, sinoflavonoids P–Z (1–11) and sinoflavonoids NA–NE (12–16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17–24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, (1)H-NMR, (13)...

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Detalles Bibliográficos
Autores principales: Sun, Yanjun, Chen, Haojie, Wang, Junmin, Gao, Meiling, Zhao, Chen, Han, Ruijie, Chen, Hui, Li, Meng, Xue, Guimin, Feng, Weisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749350/
https://www.ncbi.nlm.nih.gov/pubmed/31484370
http://dx.doi.org/10.3390/molecules24173196
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author Sun, Yanjun
Chen, Haojie
Wang, Junmin
Gao, Meiling
Zhao, Chen
Han, Ruijie
Chen, Hui
Li, Meng
Xue, Guimin
Feng, Weisheng
author_facet Sun, Yanjun
Chen, Haojie
Wang, Junmin
Gao, Meiling
Zhao, Chen
Han, Ruijie
Chen, Hui
Li, Meng
Xue, Guimin
Feng, Weisheng
author_sort Sun, Yanjun
collection PubMed
description Sixteen new prenylated flavonoids, sinoflavonoids P–Z (1–11) and sinoflavonoids NA–NE (12–16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17–24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, (1)H-NMR, (13)C-NMR, HSQC, HMBC). The cytotoxic activities of compounds 1–18, 20, and 22 were evaluated by MTT assay. Compound 6 showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC(50) values of 6.25 and 3.83 μM, respectively.
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spelling pubmed-67493502019-09-27 Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum Sun, Yanjun Chen, Haojie Wang, Junmin Gao, Meiling Zhao, Chen Han, Ruijie Chen, Hui Li, Meng Xue, Guimin Feng, Weisheng Molecules Article Sixteen new prenylated flavonoids, sinoflavonoids P–Z (1–11) and sinoflavonoids NA–NE (12–16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17–24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, (1)H-NMR, (13)C-NMR, HSQC, HMBC). The cytotoxic activities of compounds 1–18, 20, and 22 were evaluated by MTT assay. Compound 6 showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC(50) values of 6.25 and 3.83 μM, respectively. MDPI 2019-09-03 /pmc/articles/PMC6749350/ /pubmed/31484370 http://dx.doi.org/10.3390/molecules24173196 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Yanjun
Chen, Haojie
Wang, Junmin
Gao, Meiling
Zhao, Chen
Han, Ruijie
Chen, Hui
Li, Meng
Xue, Guimin
Feng, Weisheng
Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum
title Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum
title_full Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum
title_fullStr Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum
title_full_unstemmed Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum
title_short Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum
title_sort sixteen new prenylated flavonoids from the fruit of sinopodophyllum hexandrum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749350/
https://www.ncbi.nlm.nih.gov/pubmed/31484370
http://dx.doi.org/10.3390/molecules24173196
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