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A model for point of care testing for non-communicable disease diagnosis in resource-limited countries

Non-communicable disease diagnosis frequently relies on biochemical measurements but laboratory infrastructure in low-income settings is often insufficient and distances to clinics may be vast. We present a model for point of care (POC) epidemiology as used in our study of chronic disease in the Hai...

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Autores principales: Malcolm, Stuart, Cadet, Joane, Crompton, Lindsay, DeGennaro, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749552/
https://www.ncbi.nlm.nih.gov/pubmed/31555457
http://dx.doi.org/10.1017/gheg.2019.6
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author Malcolm, Stuart
Cadet, Joane
Crompton, Lindsay
DeGennaro, Vincent
author_facet Malcolm, Stuart
Cadet, Joane
Crompton, Lindsay
DeGennaro, Vincent
author_sort Malcolm, Stuart
collection PubMed
description Non-communicable disease diagnosis frequently relies on biochemical measurements but laboratory infrastructure in low-income settings is often insufficient and distances to clinics may be vast. We present a model for point of care (POC) epidemiology as used in our study of chronic disease in the Haiti Health Study, in rural and urban Haiti. Point of care testing (POCT) of creatinine, cholesterol, and hemoglobin A1c as well as physical measurements of weight, height, and waist circumference allowed for diagnosis of diabetes, chronic kidney disease, dyslipidemias, and obesity. Methods and troubleshooting techniques for the data collection of this study are presented. We discuss our method of community-health worker (CHW) training, community engagement, study design, and field data collection. We also discuss the machines used and our quality control across CHWs and across geographical regions. Pitfalls tended to include equipment malfunction, transportation issues, and cultural differences. May this paper provide information for those attempting to perform similar diagnostic and screening studies using POCT in resource poor settings.
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spelling pubmed-67495522019-09-25 A model for point of care testing for non-communicable disease diagnosis in resource-limited countries Malcolm, Stuart Cadet, Joane Crompton, Lindsay DeGennaro, Vincent Glob Health Epidemiol Genom Research Resource Non-communicable disease diagnosis frequently relies on biochemical measurements but laboratory infrastructure in low-income settings is often insufficient and distances to clinics may be vast. We present a model for point of care (POC) epidemiology as used in our study of chronic disease in the Haiti Health Study, in rural and urban Haiti. Point of care testing (POCT) of creatinine, cholesterol, and hemoglobin A1c as well as physical measurements of weight, height, and waist circumference allowed for diagnosis of diabetes, chronic kidney disease, dyslipidemias, and obesity. Methods and troubleshooting techniques for the data collection of this study are presented. We discuss our method of community-health worker (CHW) training, community engagement, study design, and field data collection. We also discuss the machines used and our quality control across CHWs and across geographical regions. Pitfalls tended to include equipment malfunction, transportation issues, and cultural differences. May this paper provide information for those attempting to perform similar diagnostic and screening studies using POCT in resource poor settings. Cambridge University Press 2019-09-11 /pmc/articles/PMC6749552/ /pubmed/31555457 http://dx.doi.org/10.1017/gheg.2019.6 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Resource
Malcolm, Stuart
Cadet, Joane
Crompton, Lindsay
DeGennaro, Vincent
A model for point of care testing for non-communicable disease diagnosis in resource-limited countries
title A model for point of care testing for non-communicable disease diagnosis in resource-limited countries
title_full A model for point of care testing for non-communicable disease diagnosis in resource-limited countries
title_fullStr A model for point of care testing for non-communicable disease diagnosis in resource-limited countries
title_full_unstemmed A model for point of care testing for non-communicable disease diagnosis in resource-limited countries
title_short A model for point of care testing for non-communicable disease diagnosis in resource-limited countries
title_sort model for point of care testing for non-communicable disease diagnosis in resource-limited countries
topic Research Resource
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749552/
https://www.ncbi.nlm.nih.gov/pubmed/31555457
http://dx.doi.org/10.1017/gheg.2019.6
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