Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies

Between 2004 and 2013, 603 patients and their relatives (n = 1297) were typed as part of the search for a suitable HLA‐matched donor in their nuclear and extended families at the central service provider for transfusion medicine at the University Hospital of Cologne. The high success rate in finding...

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Autores principales: Hellmann, Daniel M., Radojska, Stela, Fimmers, Rolf, Gathof, Birgit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749562/
https://www.ncbi.nlm.nih.gov/pubmed/30054987
http://dx.doi.org/10.1111/tan.13356
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author Hellmann, Daniel M.
Radojska, Stela
Fimmers, Rolf
Gathof, Birgit S.
author_facet Hellmann, Daniel M.
Radojska, Stela
Fimmers, Rolf
Gathof, Birgit S.
author_sort Hellmann, Daniel M.
collection PubMed
description Between 2004 and 2013, 603 patients and their relatives (n = 1297) were typed as part of the search for a suitable HLA‐matched donor in their nuclear and extended families at the central service provider for transfusion medicine at the University Hospital of Cologne. The high success rate in finding donors over the years at our center (38.1%) led us to examine our database retrospectively in order to evaluate the donor search and haplotype frequencies (HFs) in the sample. Our goal was to identify the factors contributing to this high success rate and also to compare the HFs we observed with other reported haplotype frequency estimations (HFE) for the Cologne area. Probability estimations for a successful donor search were constructed based on the HFEs for the sample.
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spelling pubmed-67495622019-09-23 Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies Hellmann, Daniel M. Radojska, Stela Fimmers, Rolf Gathof, Birgit S. HLA Original Articles Between 2004 and 2013, 603 patients and their relatives (n = 1297) were typed as part of the search for a suitable HLA‐matched donor in their nuclear and extended families at the central service provider for transfusion medicine at the University Hospital of Cologne. The high success rate in finding donors over the years at our center (38.1%) led us to examine our database retrospectively in order to evaluate the donor search and haplotype frequencies (HFs) in the sample. Our goal was to identify the factors contributing to this high success rate and also to compare the HFs we observed with other reported haplotype frequency estimations (HFE) for the Cologne area. Probability estimations for a successful donor search were constructed based on the HFEs for the sample. Blackwell Publishing Ltd 2018-09-21 2018-09 /pmc/articles/PMC6749562/ /pubmed/30054987 http://dx.doi.org/10.1111/tan.13356 Text en © 2018 The Authors. HLA published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Hellmann, Daniel M.
Radojska, Stela
Fimmers, Rolf
Gathof, Birgit S.
Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies
title Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies
title_full Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies
title_fullStr Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies
title_full_unstemmed Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies
title_short Probability of success in the search for a related bone marrow donor in Cologne, Germany using HLA‐A, ‐B and ‐DRB1 haplotype frequencies
title_sort probability of success in the search for a related bone marrow donor in cologne, germany using hla‐a, ‐b and ‐drb1 haplotype frequencies
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749562/
https://www.ncbi.nlm.nih.gov/pubmed/30054987
http://dx.doi.org/10.1111/tan.13356
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