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Blood pressure and body fat percent in women with NMOSD

BACKGROUND: Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blo...

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Autores principales: Chen, Xiaohong, Fan, Rong, Peng, Fuhua, Liu, Jia, Huang, Jing, Chen, Zhigang, Chen, Yong, Jiang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749597/
https://www.ncbi.nlm.nih.gov/pubmed/31376237
http://dx.doi.org/10.1002/brb3.1350
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author Chen, Xiaohong
Fan, Rong
Peng, Fuhua
Liu, Jia
Huang, Jing
Chen, Zhigang
Chen, Yong
Jiang, Ying
author_facet Chen, Xiaohong
Fan, Rong
Peng, Fuhua
Liu, Jia
Huang, Jing
Chen, Zhigang
Chen, Yong
Jiang, Ying
author_sort Chen, Xiaohong
collection PubMed
description BACKGROUND: Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Clínica Universidad de Navarra‐Body Adiposity Estimator (CUN‐BAE) in NMOSD has not been investigated thus far. METHODS: Case data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age‐ and sex‐matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined. RESULTS: Comparing NMOSD patients with MS patients, the former have significantly higher SBP (p < 0.001), DBP (p < 0.001), PP (p < 0.001), MAP (p < 0.001), BF% (p = 0.001), and BMI (p < 0.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110–12.453) is more likely to occur in NMOSD patients with high BF% (≥30%) at acute phase. BF% was negatively correlated with 1/AQP4 titer in NMOSD at acute phase (r = −0.522, p = 0.004). CONCLUSIONS: Women with NMOSD are probably more prone to have an increased BP and fat mass compared to MS.
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spelling pubmed-67495972019-09-23 Blood pressure and body fat percent in women with NMOSD Chen, Xiaohong Fan, Rong Peng, Fuhua Liu, Jia Huang, Jing Chen, Zhigang Chen, Yong Jiang, Ying Brain Behav Original Research BACKGROUND: Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Clínica Universidad de Navarra‐Body Adiposity Estimator (CUN‐BAE) in NMOSD has not been investigated thus far. METHODS: Case data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age‐ and sex‐matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined. RESULTS: Comparing NMOSD patients with MS patients, the former have significantly higher SBP (p < 0.001), DBP (p < 0.001), PP (p < 0.001), MAP (p < 0.001), BF% (p = 0.001), and BMI (p < 0.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110–12.453) is more likely to occur in NMOSD patients with high BF% (≥30%) at acute phase. BF% was negatively correlated with 1/AQP4 titer in NMOSD at acute phase (r = −0.522, p = 0.004). CONCLUSIONS: Women with NMOSD are probably more prone to have an increased BP and fat mass compared to MS. John Wiley and Sons Inc. 2019-08-03 /pmc/articles/PMC6749597/ /pubmed/31376237 http://dx.doi.org/10.1002/brb3.1350 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Chen, Xiaohong
Fan, Rong
Peng, Fuhua
Liu, Jia
Huang, Jing
Chen, Zhigang
Chen, Yong
Jiang, Ying
Blood pressure and body fat percent in women with NMOSD
title Blood pressure and body fat percent in women with NMOSD
title_full Blood pressure and body fat percent in women with NMOSD
title_fullStr Blood pressure and body fat percent in women with NMOSD
title_full_unstemmed Blood pressure and body fat percent in women with NMOSD
title_short Blood pressure and body fat percent in women with NMOSD
title_sort blood pressure and body fat percent in women with nmosd
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749597/
https://www.ncbi.nlm.nih.gov/pubmed/31376237
http://dx.doi.org/10.1002/brb3.1350
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