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Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage
OBJECTIVE: The aim of this study was to compare in vivo effect of five pharmacological options on inflammation and pulmonary fibrosis induced by paraquat. METHODS: 54 Wistar SPF rats were used. After 2 h post-intoxication with paraquat ion, groups of 9 animals were randomly assigned to (1) cyclophos...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749662/ https://www.ncbi.nlm.nih.gov/pubmed/31533801 http://dx.doi.org/10.1186/s13104-019-4598-0 |
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author | Buendía, Jefferson Antonio Justinico Castro, José Armando Vela, Laura Joanna Tapia Sinisterra, Denis Sánchez Villamil, Juana Patricia Zuluaga Salazar, Andrés Felipe |
author_facet | Buendía, Jefferson Antonio Justinico Castro, José Armando Vela, Laura Joanna Tapia Sinisterra, Denis Sánchez Villamil, Juana Patricia Zuluaga Salazar, Andrés Felipe |
author_sort | Buendía, Jefferson Antonio |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to compare in vivo effect of five pharmacological options on inflammation and pulmonary fibrosis induced by paraquat. METHODS: 54 Wistar SPF rats were used. After 2 h post-intoxication with paraquat ion, groups of 9 animals were randomly assigned to (1) cyclophosphamide plus dexamethasone (2) low molecular weight heparin (3) unfractionated heparin (4) vitamin C every 24 h, (5) atorvastatin or (6) placebo with intraperitoneal saline. Lung inflammation, alveolar injury, hepatocyte damage, hepatic regeneration, acute tubular necrosis and kidney congestion were evaluated. RESULTS: In the control group 100% of animals presented moderate and severe lung inflammation, while in the groups with atorvastatin and intratracheal heparin this proportion was lower (55.5%; CI 26.6–81.3%) (p = 0.025). A lower degree of moderate or severe hepatic regeneration was evident in the treatment groups with atorvastatin (p = 0.009). In this study was demonstrated that statins and heparin might have a protective effect in the paraquat-induced destructive phase. More evidence is needed to evaluated of dose–response effects of these drugs before to study in clinical trials. |
format | Online Article Text |
id | pubmed-6749662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67496622019-09-23 Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage Buendía, Jefferson Antonio Justinico Castro, José Armando Vela, Laura Joanna Tapia Sinisterra, Denis Sánchez Villamil, Juana Patricia Zuluaga Salazar, Andrés Felipe BMC Res Notes Research Note OBJECTIVE: The aim of this study was to compare in vivo effect of five pharmacological options on inflammation and pulmonary fibrosis induced by paraquat. METHODS: 54 Wistar SPF rats were used. After 2 h post-intoxication with paraquat ion, groups of 9 animals were randomly assigned to (1) cyclophosphamide plus dexamethasone (2) low molecular weight heparin (3) unfractionated heparin (4) vitamin C every 24 h, (5) atorvastatin or (6) placebo with intraperitoneal saline. Lung inflammation, alveolar injury, hepatocyte damage, hepatic regeneration, acute tubular necrosis and kidney congestion were evaluated. RESULTS: In the control group 100% of animals presented moderate and severe lung inflammation, while in the groups with atorvastatin and intratracheal heparin this proportion was lower (55.5%; CI 26.6–81.3%) (p = 0.025). A lower degree of moderate or severe hepatic regeneration was evident in the treatment groups with atorvastatin (p = 0.009). In this study was demonstrated that statins and heparin might have a protective effect in the paraquat-induced destructive phase. More evidence is needed to evaluated of dose–response effects of these drugs before to study in clinical trials. BioMed Central 2019-09-18 /pmc/articles/PMC6749662/ /pubmed/31533801 http://dx.doi.org/10.1186/s13104-019-4598-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Buendía, Jefferson Antonio Justinico Castro, José Armando Vela, Laura Joanna Tapia Sinisterra, Denis Sánchez Villamil, Juana Patricia Zuluaga Salazar, Andrés Felipe Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
title | Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
title_full | Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
title_fullStr | Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
title_full_unstemmed | Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
title_short | Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
title_sort | comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749662/ https://www.ncbi.nlm.nih.gov/pubmed/31533801 http://dx.doi.org/10.1186/s13104-019-4598-0 |
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