Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1

INTRODUCTION: The nonopioid analgesic and antipyretic dipyrone (metamizol) is frequently used worldwide. Dipyrone is a prodrug, and the metabolites 4-N-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) seem to induce analgesia and antipyresia in part by inhibiting cyclooxygenase. In mice, howev...

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Detalles Bibliográficos
Autores principales: Schenk, Stefan Alexander, Dick, Felicia, Herzog, Christine, Eberhardt, Mirjam Jeanette, Leffler, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749899/
https://www.ncbi.nlm.nih.gov/pubmed/31583344
http://dx.doi.org/10.1097/PR9.0000000000000720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749899/
https://www.ncbi.nlm.nih.gov/pubmed/31583344
http://dx.doi.org/10.1097/PR9.0000000000000720

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