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Current methods and challenges for acute pain clinical trials
INTRODUCTION: The clinical setting of acute pain has provided some of the first approaches for the development of analgesic clinical trial methods. OBJECTIVES: This article reviews current methods and challenges and provides recommendations for future design and conduct of clinical trials of interve...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749920/ https://www.ncbi.nlm.nih.gov/pubmed/31583333 http://dx.doi.org/10.1097/PR9.0000000000000647 |
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author | Gilron, Ian Carr, Daniel B. Desjardins, Paul J. Kehlet, Henrik |
author_facet | Gilron, Ian Carr, Daniel B. Desjardins, Paul J. Kehlet, Henrik |
author_sort | Gilron, Ian |
collection | PubMed |
description | INTRODUCTION: The clinical setting of acute pain has provided some of the first approaches for the development of analgesic clinical trial methods. OBJECTIVES: This article reviews current methods and challenges and provides recommendations for future design and conduct of clinical trials of interventions to treat acute pain. CONCLUSION: Growing knowledge about important diverse patient factors as well as varying pain responses to different acute pain conditions and surgical procedures has highlighted several emerging needs for acute pain trials. These include development of early-phase trial designs that minimize variability and thereby enhance assay sensitivity, minimization of bias through blinding and randomization to treatment allocation, and measurement of clinically relevant outcomes such as movement-evoked pain. However, further improvements are needed, in particular for the development of trial methods that focus on treating complex patients at high risk of severe acute pain. |
format | Online Article Text |
id | pubmed-6749920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-67499202019-10-03 Current methods and challenges for acute pain clinical trials Gilron, Ian Carr, Daniel B. Desjardins, Paul J. Kehlet, Henrik Pain Rep ACTTION Special Issue on Clinical Trials of Pain Treatments INTRODUCTION: The clinical setting of acute pain has provided some of the first approaches for the development of analgesic clinical trial methods. OBJECTIVES: This article reviews current methods and challenges and provides recommendations for future design and conduct of clinical trials of interventions to treat acute pain. CONCLUSION: Growing knowledge about important diverse patient factors as well as varying pain responses to different acute pain conditions and surgical procedures has highlighted several emerging needs for acute pain trials. These include development of early-phase trial designs that minimize variability and thereby enhance assay sensitivity, minimization of bias through blinding and randomization to treatment allocation, and measurement of clinically relevant outcomes such as movement-evoked pain. However, further improvements are needed, in particular for the development of trial methods that focus on treating complex patients at high risk of severe acute pain. Wolters Kluwer 2018-04-02 /pmc/articles/PMC6749920/ /pubmed/31583333 http://dx.doi.org/10.1097/PR9.0000000000000647 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0 (CC BY-ND) (http://creativecommons.org/licenses/by-nd/4.0/) which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. |
spellingShingle | ACTTION Special Issue on Clinical Trials of Pain Treatments Gilron, Ian Carr, Daniel B. Desjardins, Paul J. Kehlet, Henrik Current methods and challenges for acute pain clinical trials |
title | Current methods and challenges for acute pain clinical trials |
title_full | Current methods and challenges for acute pain clinical trials |
title_fullStr | Current methods and challenges for acute pain clinical trials |
title_full_unstemmed | Current methods and challenges for acute pain clinical trials |
title_short | Current methods and challenges for acute pain clinical trials |
title_sort | current methods and challenges for acute pain clinical trials |
topic | ACTTION Special Issue on Clinical Trials of Pain Treatments |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749920/ https://www.ncbi.nlm.nih.gov/pubmed/31583333 http://dx.doi.org/10.1097/PR9.0000000000000647 |
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