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Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma

PURPOSE: To assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in stage II nasopharyngeal carcinoma (NPC). METHODS: Stage II (2010 UICC/AJCC staging system) NPC patients treated between January 2007 and December 2014 were retrospectively analyzed. The NLR was calculated from per...

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Autores principales: Pan, Xin-Bin, Huang, Shi-Ting, Zhu, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749985/
https://www.ncbi.nlm.nih.gov/pubmed/31571984
http://dx.doi.org/10.2147/CMAR.S213264
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author Pan, Xin-Bin
Huang, Shi-Ting
Zhu, Xiao-Dong
author_facet Pan, Xin-Bin
Huang, Shi-Ting
Zhu, Xiao-Dong
author_sort Pan, Xin-Bin
collection PubMed
description PURPOSE: To assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in stage II nasopharyngeal carcinoma (NPC). METHODS: Stage II (2010 UICC/AJCC staging system) NPC patients treated between January 2007 and December 2014 were retrospectively analyzed. The NLR was calculated from peripheral blood cell counts before treatment. The optimal cut-off value of NLR was determined by receiver operating characteristic curve analysis. Survival rates were compared according to the NLR value. Multivariable Cox regression analyses were performed to assess the association between the NLR and overall survival (OS), locoregional-free survival (LRFS), and distant metastasis-free survival (DMFS). RESULTS: Two hundred and fifty-one stage II NPC patients were included in this study. The NLR was correlated with T stage (r=0.158, p=0.012). An NLR ≥2.92 was associated with poor 5-year OS (84.3% vs 97.4%, p=0.001) and LRFS (91.4% vs 98.4%, p=0.003). An NLR ≥2.82 was associated with poor 5-year DMFS (92.6% vs 98.2%, p=0.033). The multivariate Cox regression analysis showed that an NLR ≥2.92 was an independent prognostic biomarker in stage II NPC. CONCLUSION: The NLR is an independent prognostic factor in stage II NPC.
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spelling pubmed-67499852019-09-30 Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma Pan, Xin-Bin Huang, Shi-Ting Zhu, Xiao-Dong Cancer Manag Res Original Research PURPOSE: To assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in stage II nasopharyngeal carcinoma (NPC). METHODS: Stage II (2010 UICC/AJCC staging system) NPC patients treated between January 2007 and December 2014 were retrospectively analyzed. The NLR was calculated from peripheral blood cell counts before treatment. The optimal cut-off value of NLR was determined by receiver operating characteristic curve analysis. Survival rates were compared according to the NLR value. Multivariable Cox regression analyses were performed to assess the association between the NLR and overall survival (OS), locoregional-free survival (LRFS), and distant metastasis-free survival (DMFS). RESULTS: Two hundred and fifty-one stage II NPC patients were included in this study. The NLR was correlated with T stage (r=0.158, p=0.012). An NLR ≥2.92 was associated with poor 5-year OS (84.3% vs 97.4%, p=0.001) and LRFS (91.4% vs 98.4%, p=0.003). An NLR ≥2.82 was associated with poor 5-year DMFS (92.6% vs 98.2%, p=0.033). The multivariate Cox regression analysis showed that an NLR ≥2.92 was an independent prognostic biomarker in stage II NPC. CONCLUSION: The NLR is an independent prognostic factor in stage II NPC. Dove 2019-09-09 /pmc/articles/PMC6749985/ /pubmed/31571984 http://dx.doi.org/10.2147/CMAR.S213264 Text en © 2019 Pan et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Pan, Xin-Bin
Huang, Shi-Ting
Zhu, Xiao-Dong
Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma
title Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma
title_full Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma
title_fullStr Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma
title_full_unstemmed Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma
title_short Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma
title_sort neutrophil-to-lymphocyte ratio predicts the prognosis of stage ii nasopharyngeal carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749985/
https://www.ncbi.nlm.nih.gov/pubmed/31571984
http://dx.doi.org/10.2147/CMAR.S213264
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