Multilayer 3D Chirality and Its Synthetic Assembly

3D chirality of sandwich type of organic molecules has been discovered. The key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane. Individual enantiomers of these molecules have bee...

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Autores principales: Wu, Guanzhao, Liu, Yangxue, Yang, Zhen, Katakam, Nandakumar, Rouh, Hossein, Ahmed, Sultan, Unruh, Daniel, Surowiec, Kazimierz, Li, Guigen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750085/
https://www.ncbi.nlm.nih.gov/pubmed/31549078
http://dx.doi.org/10.34133/2019/6717104
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author Wu, Guanzhao
Liu, Yangxue
Yang, Zhen
Katakam, Nandakumar
Rouh, Hossein
Ahmed, Sultan
Unruh, Daniel
Surowiec, Kazimierz
Li, Guigen
author_facet Wu, Guanzhao
Liu, Yangxue
Yang, Zhen
Katakam, Nandakumar
Rouh, Hossein
Ahmed, Sultan
Unruh, Daniel
Surowiec, Kazimierz
Li, Guigen
author_sort Wu, Guanzhao
collection PubMed
description 3D chirality of sandwich type of organic molecules has been discovered. The key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane. Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC. The absolute configuration was unambiguously assigned by X-ray diffraction analysis. This is the first multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synthesis and catalysis and to have a broad impact on chemical, medicinal, and material sciences in future.
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spelling pubmed-67500852019-09-23 Multilayer 3D Chirality and Its Synthetic Assembly Wu, Guanzhao Liu, Yangxue Yang, Zhen Katakam, Nandakumar Rouh, Hossein Ahmed, Sultan Unruh, Daniel Surowiec, Kazimierz Li, Guigen Research (Wash D C) Research Article 3D chirality of sandwich type of organic molecules has been discovered. The key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane. Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC. The absolute configuration was unambiguously assigned by X-ray diffraction analysis. This is the first multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synthesis and catalysis and to have a broad impact on chemical, medicinal, and material sciences in future. AAAS 2019-06-27 /pmc/articles/PMC6750085/ /pubmed/31549078 http://dx.doi.org/10.34133/2019/6717104 Text en Copyright © 2019 Guanzhao Wu et al. https://creativecommons.org/licenses/by/4.0/ Exclusive licensee Science and Technology Review Publishing House. Distributed under a Creative Commons Attribution License (CC BY 4.0).
spellingShingle Research Article
Wu, Guanzhao
Liu, Yangxue
Yang, Zhen
Katakam, Nandakumar
Rouh, Hossein
Ahmed, Sultan
Unruh, Daniel
Surowiec, Kazimierz
Li, Guigen
Multilayer 3D Chirality and Its Synthetic Assembly
title Multilayer 3D Chirality and Its Synthetic Assembly
title_full Multilayer 3D Chirality and Its Synthetic Assembly
title_fullStr Multilayer 3D Chirality and Its Synthetic Assembly
title_full_unstemmed Multilayer 3D Chirality and Its Synthetic Assembly
title_short Multilayer 3D Chirality and Its Synthetic Assembly
title_sort multilayer 3d chirality and its synthetic assembly
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750085/
https://www.ncbi.nlm.nih.gov/pubmed/31549078
http://dx.doi.org/10.34133/2019/6717104
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