Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a promising target for drug and pesticide discovery. The unknown binding mode of substrate is still a big challenge for the understanding of enzymatic reaction mechanism and novel HPPD inhibitor design. Herein, we determined the first crystal structure o...

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Detalles Bibliográficos
Autores principales: Lin, Hong-Yan, Chen, Xi, Chen, Jia-Nan, Wang, Da-Wei, Wu, Feng-Xu, Lin, Song-Yun, Zhan, Chang-Guo, Wu, Jia-Wei, Yang, Wen-Chao, Yang, Guang-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750108/
https://www.ncbi.nlm.nih.gov/pubmed/31549053
http://dx.doi.org/10.34133/2019/2602414

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