Evaluating the IgMi mouse as a novel tool to study B‐cell biology

The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B‐cell subsets, DC subsets, GC B cells and T(FH) cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse...

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Detalles Bibliográficos
Autores principales: Sahputra, Rinal, Yam‐Puc, Juan Carlos, Waisman, Ari, Muller, Werner, Else, Kathryn J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750126/
https://www.ncbi.nlm.nih.gov/pubmed/30315705
http://dx.doi.org/10.1002/eji.201847735
Descripción
Sumario:The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B‐cell subsets, DC subsets, GC B cells and T(FH) cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody. [Image: see text]

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