Evaluating the IgMi mouse as a novel tool to study B‐cell biology

The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B‐cell subsets, DC subsets, GC B cells and T(FH) cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse...

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Detalles Bibliográficos
Autores principales: Sahputra, Rinal, Yam‐Puc, Juan Carlos, Waisman, Ari, Muller, Werner, Else, Kathryn J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750126/
https://www.ncbi.nlm.nih.gov/pubmed/30315705
http://dx.doi.org/10.1002/eji.201847735
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author Sahputra, Rinal
Yam‐Puc, Juan Carlos
Waisman, Ari
Muller, Werner
Else, Kathryn J
author_facet Sahputra, Rinal
Yam‐Puc, Juan Carlos
Waisman, Ari
Muller, Werner
Else, Kathryn J
author_sort Sahputra, Rinal
collection PubMed
description The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B‐cell subsets, DC subsets, GC B cells and T(FH) cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody. [Image: see text]
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spelling pubmed-67501262019-09-23 Evaluating the IgMi mouse as a novel tool to study B‐cell biology Sahputra, Rinal Yam‐Puc, Juan Carlos Waisman, Ari Muller, Werner Else, Kathryn J Eur J Immunol Letter to the Editor The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B‐cell subsets, DC subsets, GC B cells and T(FH) cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody. [Image: see text] John Wiley and Sons Inc. 2018-10-26 2018-12 /pmc/articles/PMC6750126/ /pubmed/30315705 http://dx.doi.org/10.1002/eji.201847735 Text en © 2018 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Sahputra, Rinal
Yam‐Puc, Juan Carlos
Waisman, Ari
Muller, Werner
Else, Kathryn J
Evaluating the IgMi mouse as a novel tool to study B‐cell biology
title Evaluating the IgMi mouse as a novel tool to study B‐cell biology
title_full Evaluating the IgMi mouse as a novel tool to study B‐cell biology
title_fullStr Evaluating the IgMi mouse as a novel tool to study B‐cell biology
title_full_unstemmed Evaluating the IgMi mouse as a novel tool to study B‐cell biology
title_short Evaluating the IgMi mouse as a novel tool to study B‐cell biology
title_sort evaluating the igmi mouse as a novel tool to study b‐cell biology
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750126/
https://www.ncbi.nlm.nih.gov/pubmed/30315705
http://dx.doi.org/10.1002/eji.201847735
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