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Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology
To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM). Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBB...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750260/ https://www.ncbi.nlm.nih.gov/pubmed/31517829 http://dx.doi.org/10.1097/MD.0000000000017082 |
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author | Wienbeck, Susanne Uhlig, Johannes Fischer, Uwe Hellriegel, Martin von Fintel, Eva Kulenkampff, Dietrich Surov, Alexey Lotz, Joachim Perske, Christina |
author_facet | Wienbeck, Susanne Uhlig, Johannes Fischer, Uwe Hellriegel, Martin von Fintel, Eva Kulenkampff, Dietrich Surov, Alexey Lotz, Joachim Perske, Christina |
author_sort | Wienbeck, Susanne |
collection | PubMed |
description | To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM). Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology. A total of 94 lesions (40 patients) were included. Histopathological analyses revealed 47 malignant, 6 high-risk, and 41 benign lesions. Mean histopathological lesion size was 20.8 mm (range 2–100). Mean absolute size deviation from histopathology was largest for FFDM (5.3 ± 6.7 mm) and smallest for CBBCT 50 mA, high-resolution mode (4.3 ± 6.7 mm). Differences between imaging modalities did not reach statistical significance (P = .85). All imaging methods tend to overestimate breast lesion size compared to histopathological gold standard. No significant differences were found regarding size measurements, although in tendency CBBCT showed better lesion detection and cT classification over FFDM. |
format | Online Article Text |
id | pubmed-6750260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-67502602019-10-03 Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology Wienbeck, Susanne Uhlig, Johannes Fischer, Uwe Hellriegel, Martin von Fintel, Eva Kulenkampff, Dietrich Surov, Alexey Lotz, Joachim Perske, Christina Medicine (Baltimore) 4100 To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM). Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology. A total of 94 lesions (40 patients) were included. Histopathological analyses revealed 47 malignant, 6 high-risk, and 41 benign lesions. Mean histopathological lesion size was 20.8 mm (range 2–100). Mean absolute size deviation from histopathology was largest for FFDM (5.3 ± 6.7 mm) and smallest for CBBCT 50 mA, high-resolution mode (4.3 ± 6.7 mm). Differences between imaging modalities did not reach statistical significance (P = .85). All imaging methods tend to overestimate breast lesion size compared to histopathological gold standard. No significant differences were found regarding size measurements, although in tendency CBBCT showed better lesion detection and cT classification over FFDM. Wolters Kluwer Health 2019-09-13 /pmc/articles/PMC6750260/ /pubmed/31517829 http://dx.doi.org/10.1097/MD.0000000000017082 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4100 Wienbeck, Susanne Uhlig, Johannes Fischer, Uwe Hellriegel, Martin von Fintel, Eva Kulenkampff, Dietrich Surov, Alexey Lotz, Joachim Perske, Christina Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology |
title | Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology |
title_full | Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology |
title_fullStr | Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology |
title_full_unstemmed | Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology |
title_short | Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology |
title_sort | breast lesion size assessment in mastectomy specimens: correlation of cone-beam breast-ct, digital breast tomosynthesis and full-field digital mammography with histopathology |
topic | 4100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750260/ https://www.ncbi.nlm.nih.gov/pubmed/31517829 http://dx.doi.org/10.1097/MD.0000000000017082 |
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