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Sera total oxidant/antioxidant status in lung cancer patients

We investigated oxidative stress parameters in the sera of patients with lung cancer and healthy individuals to evaluate their correlations with lung cancer. Ninety-four lung cancer patients and 64 healthy controls were enrolled after obtaining informed consent. Their sera oxidative stress parameter...

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Autores principales: Xiang, Miao, Feng, Jiafu, Geng, Lidan, Yang, Yuwei, Dai, Chunmei, Li, Jie, Liao, Yao, Wang, Dong, Du, Xiao-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750341/
https://www.ncbi.nlm.nih.gov/pubmed/31517874
http://dx.doi.org/10.1097/MD.0000000000017179
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author Xiang, Miao
Feng, Jiafu
Geng, Lidan
Yang, Yuwei
Dai, Chunmei
Li, Jie
Liao, Yao
Wang, Dong
Du, Xiao-Bo
author_facet Xiang, Miao
Feng, Jiafu
Geng, Lidan
Yang, Yuwei
Dai, Chunmei
Li, Jie
Liao, Yao
Wang, Dong
Du, Xiao-Bo
author_sort Xiang, Miao
collection PubMed
description We investigated oxidative stress parameters in the sera of patients with lung cancer and healthy individuals to evaluate their correlations with lung cancer. Ninety-four lung cancer patients and 64 healthy controls were enrolled after obtaining informed consent. Their sera oxidative stress parameters were measured. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were significantly different between patients and healthy groups (all P < .001). TAS gradually decreased and TOS and OSI gradually increased from stage I to III, but it did not reach statistical significance (all P > .05). TAS and OSI were significantly different between the nonsmoking and smoking groups, radiotherapy and without radiotherapy groups, chemotherapy and without chemotherapy groups (P < .05), but not TOS (P > .05). In a receiver operating characteristic curve analysis comparing patients with lung cancer with healthy controls, the Youden indices of TOS, TAS, and OSI were 0.541, 0.532, and 1, respectively. The oxidative stress may be correlation with lung cancer staging. Smoking, surgery, radiotherapy, and chemotherapy showed correlation with parts oxidative stress parameters.
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spelling pubmed-67503412019-10-03 Sera total oxidant/antioxidant status in lung cancer patients Xiang, Miao Feng, Jiafu Geng, Lidan Yang, Yuwei Dai, Chunmei Li, Jie Liao, Yao Wang, Dong Du, Xiao-Bo Medicine (Baltimore) 5700 We investigated oxidative stress parameters in the sera of patients with lung cancer and healthy individuals to evaluate their correlations with lung cancer. Ninety-four lung cancer patients and 64 healthy controls were enrolled after obtaining informed consent. Their sera oxidative stress parameters were measured. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were significantly different between patients and healthy groups (all P < .001). TAS gradually decreased and TOS and OSI gradually increased from stage I to III, but it did not reach statistical significance (all P > .05). TAS and OSI were significantly different between the nonsmoking and smoking groups, radiotherapy and without radiotherapy groups, chemotherapy and without chemotherapy groups (P < .05), but not TOS (P > .05). In a receiver operating characteristic curve analysis comparing patients with lung cancer with healthy controls, the Youden indices of TOS, TAS, and OSI were 0.541, 0.532, and 1, respectively. The oxidative stress may be correlation with lung cancer staging. Smoking, surgery, radiotherapy, and chemotherapy showed correlation with parts oxidative stress parameters. Wolters Kluwer Health 2019-09-13 /pmc/articles/PMC6750341/ /pubmed/31517874 http://dx.doi.org/10.1097/MD.0000000000017179 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Xiang, Miao
Feng, Jiafu
Geng, Lidan
Yang, Yuwei
Dai, Chunmei
Li, Jie
Liao, Yao
Wang, Dong
Du, Xiao-Bo
Sera total oxidant/antioxidant status in lung cancer patients
title Sera total oxidant/antioxidant status in lung cancer patients
title_full Sera total oxidant/antioxidant status in lung cancer patients
title_fullStr Sera total oxidant/antioxidant status in lung cancer patients
title_full_unstemmed Sera total oxidant/antioxidant status in lung cancer patients
title_short Sera total oxidant/antioxidant status in lung cancer patients
title_sort sera total oxidant/antioxidant status in lung cancer patients
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750341/
https://www.ncbi.nlm.nih.gov/pubmed/31517874
http://dx.doi.org/10.1097/MD.0000000000017179
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