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The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon

In the Americas, as in much of the rest of the world, the dengue virus vector Aedes aegypti is found in close association with human habitations, often leading to high population densities of mosquitoes in urban settings. In the Peruvian Amazon, this vector has been expanding to rural communities ov...

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Autores principales: Guagliardo, Sarah Anne J., Lee, Yoosook, Pierce, Amanda A., Wong, Jacklyn, Chu, Yui Yin, Morrison, Amy C., Astete, Helvio, Brosi, Berry, Vazquez-Prokopec, Gonzalo, Scott, Thomas W., Kitron, Uriel, Stoddard, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750575/
https://www.ncbi.nlm.nih.gov/pubmed/31532762
http://dx.doi.org/10.1371/journal.pntd.0007552
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author Guagliardo, Sarah Anne J.
Lee, Yoosook
Pierce, Amanda A.
Wong, Jacklyn
Chu, Yui Yin
Morrison, Amy C.
Astete, Helvio
Brosi, Berry
Vazquez-Prokopec, Gonzalo
Scott, Thomas W.
Kitron, Uriel
Stoddard, Steven T.
author_facet Guagliardo, Sarah Anne J.
Lee, Yoosook
Pierce, Amanda A.
Wong, Jacklyn
Chu, Yui Yin
Morrison, Amy C.
Astete, Helvio
Brosi, Berry
Vazquez-Prokopec, Gonzalo
Scott, Thomas W.
Kitron, Uriel
Stoddard, Steven T.
author_sort Guagliardo, Sarah Anne J.
collection PubMed
description In the Americas, as in much of the rest of the world, the dengue virus vector Aedes aegypti is found in close association with human habitations, often leading to high population densities of mosquitoes in urban settings. In the Peruvian Amazon, this vector has been expanding to rural communities over the last 10–15 years, but to date, the population genetic structure of Ae. aegypti in this region has not been characterized. To investigate the relationship between Ae. aegypti gene flow and human transportation networks, we characterized mosquito population structure using a panel of 8 microsatellite markers and linked results to various potential mechanisms for long-distance dispersal. Adult and immature Ae. aegypti (>20 individuals per site) were collected from Iquitos city and from six neighboring riverine communities, i.e., Nauta, Indiana, Mazan, Barrio Florida, Tamshiaco, and Aucayo. F(ST) statistics indicate significant, but low to moderate differentiation for the majority of study site pairs. Population structure of Ae. aegypti is not correlated with the geographic distance between towns, suggesting that human transportation networks provide a reasonable explanation for the high levels of population mixing. Our results indicate that Ae. aegypti gene flow among sub-populations is greatest between locations with heavy boat traffic, such as Iquitos-Tamshiaco and Iquitos-Indiana-Mazan, and lowest between locations with little or no boat/road traffic between them such as Barrio Florida-Iquitos. Bayesian clustering analysis showed ancestral admixture among three genetic clusters; no single cluster was exclusive to any site. Our results are consistent with the hypothesis that human transportation networks, particularly riverways, are responsible for the geographic spread of Ae. aegypti in the Peruvian Amazon. Our findings are applicable to other regions of the world characterized by networks of urban islands connected by fluvial transport routes.
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spelling pubmed-67505752019-09-27 The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon Guagliardo, Sarah Anne J. Lee, Yoosook Pierce, Amanda A. Wong, Jacklyn Chu, Yui Yin Morrison, Amy C. Astete, Helvio Brosi, Berry Vazquez-Prokopec, Gonzalo Scott, Thomas W. Kitron, Uriel Stoddard, Steven T. PLoS Negl Trop Dis Research Article In the Americas, as in much of the rest of the world, the dengue virus vector Aedes aegypti is found in close association with human habitations, often leading to high population densities of mosquitoes in urban settings. In the Peruvian Amazon, this vector has been expanding to rural communities over the last 10–15 years, but to date, the population genetic structure of Ae. aegypti in this region has not been characterized. To investigate the relationship between Ae. aegypti gene flow and human transportation networks, we characterized mosquito population structure using a panel of 8 microsatellite markers and linked results to various potential mechanisms for long-distance dispersal. Adult and immature Ae. aegypti (>20 individuals per site) were collected from Iquitos city and from six neighboring riverine communities, i.e., Nauta, Indiana, Mazan, Barrio Florida, Tamshiaco, and Aucayo. F(ST) statistics indicate significant, but low to moderate differentiation for the majority of study site pairs. Population structure of Ae. aegypti is not correlated with the geographic distance between towns, suggesting that human transportation networks provide a reasonable explanation for the high levels of population mixing. Our results indicate that Ae. aegypti gene flow among sub-populations is greatest between locations with heavy boat traffic, such as Iquitos-Tamshiaco and Iquitos-Indiana-Mazan, and lowest between locations with little or no boat/road traffic between them such as Barrio Florida-Iquitos. Bayesian clustering analysis showed ancestral admixture among three genetic clusters; no single cluster was exclusive to any site. Our results are consistent with the hypothesis that human transportation networks, particularly riverways, are responsible for the geographic spread of Ae. aegypti in the Peruvian Amazon. Our findings are applicable to other regions of the world characterized by networks of urban islands connected by fluvial transport routes. Public Library of Science 2019-09-18 /pmc/articles/PMC6750575/ /pubmed/31532762 http://dx.doi.org/10.1371/journal.pntd.0007552 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Guagliardo, Sarah Anne J.
Lee, Yoosook
Pierce, Amanda A.
Wong, Jacklyn
Chu, Yui Yin
Morrison, Amy C.
Astete, Helvio
Brosi, Berry
Vazquez-Prokopec, Gonzalo
Scott, Thomas W.
Kitron, Uriel
Stoddard, Steven T.
The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon
title The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon
title_full The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon
title_fullStr The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon
title_full_unstemmed The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon
title_short The genetic structure of Aedes aegypti populations is driven by boat traffic in the Peruvian Amazon
title_sort genetic structure of aedes aegypti populations is driven by boat traffic in the peruvian amazon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750575/
https://www.ncbi.nlm.nih.gov/pubmed/31532762
http://dx.doi.org/10.1371/journal.pntd.0007552
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